Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

详细信息    查看全文

• 作者：R.L. Openshaw ; D.M. Thomson ; J.M. Penninger ; J.A. Pratt ; B.J. Morris
• 关键词：Cognition ; Attention ; MKK7 ; JNK ; MAP kinase
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：234
• 期：2
• 页码：293-305
• 全文大小：921KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

RationaleMembers of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear.