The 16-year incidence, progression and regression of diabetic retinopathy in a young population-based Danish cohort with type 1 diabetes mellitus: The Danish cohort of pediatric diabetes 1987 (DCPD1987)
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- 作者：Rebecca Broe (1) (2) (3)
Malin Lundberg Rasmussen (1) (2)
Ulrik Frydkjaer-Olsen (1) (2)
Birthe Susanne Olsen (4) (5)
Henrik Bindesboel Mortensen (4) (5)
Tunde Peto (2) (6)
Jakob Grauslund (1) (2) - 关键词：Non ; proliferative diabetic retinopathy ; Proliferative diabetic retinopathy ; Risk factors ; Incidence ; Type 1 diabetes mellitus ; Population ; based
- 刊名：Acta Diabetologica
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：51
- 期：3
- 页码：413-420
- 全文大小：
- 参考文献：1. Reichard P, Nilsson BY, Rosenqvist U (1993) The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 329(5):304-09. doi:10.1056/nejm199307293290502 CrossRef
2. Anonymous (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329 (14):977-86 doi:10.1056/nejm199309303291401
3. Wang PH, Lau J, Chalmers TC (1993) Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes. Lancet 341(8856):1306-309 CrossRef
4. Chaturvedi N, Sjolie AK, Stephenson JM, Abrahamian H, Keipes M, Castellarin A, Rogulja-Pepeonik Z, Fuller JH (1998) Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus. Lancet 351(9095):28-1 CrossRef
5. Anonymous (1998) Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. BMJ (Clinical research ed) 317 (7160):703-13
6. Nordwall M, Bojestig M, Arnqvist HJ, Ludvigsson J (2004) Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of Type 1 diabetes-the Linkoping Diabetes Complications Study. Diabetologia 47(7):1266-272. doi:10.1007/s00125-004-1431-6 CrossRef
7. Kyto JP, Harjutsalo V, Forsblom C, Hietala K, Summanen PA, Groop PH (2011) Decline in the cumulative incidence of severe diabetic retinopathy in patients with type 1 diabetes. Diabetes Care 34(9):2005-007. doi:10.2337/dc10-2391 CrossRef
8. Hovind P, Tarnow L, Rossing K, Rossing P, Eising S, Larsen N, Binder C, Parving HH (2003) Decreasing incidence of severe diabetic microangiopathy in type 1 diabetes. Diabetes Care 26(4):1258-264 CrossRef
9. Klein R, Knudtson MD, Lee KE, Gangnon R, Klein BE (2008) The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalmology 115(11):1859-868. doi:10.1016/j.ophtha.2008.08.023 CrossRef
10. Pambianco G, Costacou T, Ellis D, Becker DJ, Klein R, Orchard TJ (2006) The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience. Diabetes 55(5):1463-469 CrossRef
11. Rossing K, Jacobsen P, Rossing P, Lauritzen E, Lund-Andersen H, Parving HH (1998) Improved visual function in IDDM patients with unchanged cumulative incidence of sight-threatening diabetic retinopathy. Diabetes Care 21(11):2007-015 CrossRef
12. Bojestig M, Arnqvist HJ, Karlberg BE, Ludvigsson J (1998) Unchanged incidence of severe retinopathy in a population of Type 1 diabetic patients with marked reduction of nephropathy. Diabet Med J Br Diabet Assoc 15(10):863-69. doi:10.1002/(sici)1096-9136(199810)15:10<863:aid-dia665>3.0.co;2-o CrossRef
13. Mortensen HB, Hartling SG, Petersen KE (1988) A nation-wide cross-sectional study of glycosylated haemoglobin in Danish children with type 1 diabetes. Diabet Med J Br Diabet Assoc 5(9):871-76 CrossRef
14. Mortensen HB, Marinelli K, Norgaard K, Main K, Kastrup KW, Ibsen KK, Villumsen J, Parving HH (1990) A nation-wide cross-sectional study of urinary albumin excretion rate, arterial blood pressure and blood glucose control in Danish children with type 1 diabetes mellitus. Danish Study Group of Diabetes in Childhood. Diabet Med J Br Diabet Assoc 7(10):887-97 CrossRef
15. Mortensen HB, Villumsen J, Volund A, Petersen KE, Nerup J (1992) Relationship between insulin injection regimen and metabolic control in young Danish type 1 diabetic patients. The Danish Study Group of Diabetes in Childhood. Diabet Med J Br Diabet Assoc 9(9):834-39 CrossRef
16. Mortensen HB, Hougaard P, Ibsen KK, Parving HH (1994) Relationship between blood pressure and urinary albumin excretion rate in young Danish type 1 diabetic patients: comparison to non-diabetic children. Danish Study Group of Diabetes in Childhood. Diabet Med J Br Diabet Assoc 11(2):155-61 CrossRef
17. Olsen BS, Johannesen J, Sjolie AK, Borch-Johnsen K, Hougarrdss P, Thorsteinsson B, Prammingss S, Marinelli K, Mortensen HB (1999) Metabolic control and prevalence of microvascular complications in young Danish patients with Type 1 diabetes mellitus. Danish Study Group of Diabetes in Childhood. Diabet Med J Br Diabet Assoc 16(1):79-5 CrossRef
18. Olsen BS, Sjolie A, Hougaard P, Johannesen J, Borch-Johnsen K, Marinelli K, Thorsteinsson B, Pramming S, Mortensen HB (2000) A 6-year nationwide cohort study of glycaemic control in young people with type 1 diabetes. Risk markers for the development of retinopathy, nephropathy and neuropathy. Danish Study Group of Diabetes in Childhood. J Diabetes Complicat 14(6):295-00 CrossRef
19. Olsen BS, Sjolie AK, Hougaard P, Johannesen J, Marinelli K, Jacobsen BB, Mortensen HB (2004) The significance of the prepubertal diabetes duration for the development of retinopathy and nephropathy in patients with type 1 diabetes. J Diabetes Complicat 18(3):160-64. doi:10.1016/s1056-8727(03)00073-4 CrossRef
20. Aldington SJ, Kohner EM, Meuer S, Klein R, Sjolie AK (1995) Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM complications study. Diabetologia 38(4):437-44 CrossRef
21. Anonymous (1985) Early Treatment Diabetic Retinopathy Study (ETDRS): Manual of Operations. U.S. Department of Commerce, National Technical Information Service
22. Anonymous (1991) Grading diabetic retinopathy from stereoscopic color fundus photographs—an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 98 (5 Suppl):786-06
23. Anonymous (1991) Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 98 (5 Suppl):823-33
24. Klein R, Klein BE, Moss SE, Cruickshanks KJ (1998) The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmology 105(10):1801-815. doi:10.1016/s0161-6420(98)91020-x CrossRef
25. Grauslund J, Green A, Sjolie AK (2009) Prevalence and 25?year incidence of proliferative retinopathy among Danish type 1 diabetic patients. Diabetologia 52(9):1829-835. doi:10.1007/s00125-009-1450-4 CrossRef
26. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL (1984) The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30?years. Arch Ophthalmol 102(4):520-26 CrossRef
27. Orchard TJ, Dorman JS, Maser RE, Becker DJ, Drash AL, Ellis D, LaPorte RE, Kuller LH (1990) Prevalence of complications in IDDM by sex and duration. Pittsburgh Epidemiology of Diabetes Complications Study II. Diabetes 39(9):1116-124 CrossRef
28. Porta M, Sjoelie AK, Chaturvedi N, Stevens L, Rottiers R, Veglio M, Fuller JH (2001) Risk factors for progression to proliferative diabetic retinopathy in the EURODIAB Prospective Complications Study. Diabetologia 44(12):2203-209. doi:10.1007/s001250100030 CrossRef
29. Lovestam-Adrian M, Agardh CD, Torffvit O, Agardh E (2001) Diabetic retinopathy, visual acuity, and medical risk indicators: a continuous 10-year follow-up study in Type 1 diabetic patients under routine care. J Diabetes Complicat 15(6):287-94 CrossRef
30. Janka HU, Warram JH, Rand LI, Krolewski AS (1989) Risk factors for progression of background retinopathy in long-standing IDDM. Diabetes 38(4):460-64 CrossRef
31. Skrivarhaug T, Fosmark DS, Stene LC, Bangstad HJ, Sandvik L, Hanssen KF, Joner G (2006) Low cumulative incidence of proliferative retinopathy in childhood-onset type 1 diabetes: a 24-year follow-up study. Diabetologia 49(10):2281-290. doi:10.1007/s00125-006-0364-7 CrossRef
32. Krolewski AS, Warram JH, Rand LI, Christlieb AR, Busick EJ, Kahn CR (1986) Risk of proliferative diabetic retinopathy in juvenile-onset type I diabetes: a 40-yr follow-up study. Diabetes Care 9(5):443-52 CrossRef - 作者单位：Rebecca Broe (1) (2) (3)
Malin Lundberg Rasmussen (1) (2)
Ulrik Frydkjaer-Olsen (1) (2)
Birthe Susanne Olsen (4) (5)
Henrik Bindesboel Mortensen (4) (5)
Tunde Peto (2) (6)
Jakob Grauslund (1) (2)
1. Department of Ophthalmology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark
2. The Clinical Research Institute, University of Southern Denmark, Odense, Denmark
3. OPEN Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark
4. Department of Pediatrics E, Herlev Hospital, Herlev, Denmark
5. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
6. The NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK - ISSN：1432-5233
文摘
The aim was to investigate the long-term incidence of proliferative diabetic retinopathy (PDR), and progression and regression of diabetic retinopathy (DR) and associated risk factors in young Danish patients with Type 1 diabetes mellitus. In 1987-9, a pediatric cohort involving approximately 75?% of all children with Type 1 diabetes in Denmark <19?years of age was identified (n?=?720). In 1995, 339 (47.1?%) were re-studied with retinopathy graded and all relevant diabetic parameters assessed. Of those, 185 (54.6?%) were evaluated again in 2011 for the same clinical parameters. All retinal images were graded using modified early treatment of DR study for 1995 and 2011. In 1995, mean age was 21.0?years and mean diabetes duration 13.5?years. The 16-year incidence of proliferative retinopathy, 2-step progression and 2-step regression of DR was 31.0, 64.4 and 0.0?%, respectively, while the incidence of DR was 95.1?%. In a multivariate logistic regression model, progression to PDR was significantly associated with 1995 HbA1c (OR 2.61 per 1?% increase, 95?% CI 1.85-.68) and 1995 diastolic blood pressure (OR 1.79 per 10?mmHg increase, 95?% CI 1.04-.07). Two-step progression of DR was associated with male gender (OR 2.37 vs. female, 95?% CI 1.07-.27), 1995 HbA1c (OR 3.02 per 1?% increase, 95?% CI 2.04-.48) and 1995 vibration perception threshold (OR 1.19 per 1?Volt increase, 95?% CI 1.02-.40). In conclusion, one in three progressed to PDR and two in three had 2-step progression despite young age and increased awareness of the importance of metabolic control. After 30?years duration of diabetes, the presence of DR is almost universal.