Role of pericellular proteolysis by membrane‐type 1 matrix metalloproteinase in cancer invasion and angiogenesis

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• 作者：Seiki ; Motoharu ; Koshikawa ; Naohiko ; Yana ; Ikuo
• 关键词：pericellular proteolysis ; MT1 ; MMP ; MMP ; 2 ; cancer ; invasion and metastasis ; migration
• 刊名：Cancer and Metastasis Reviews
• 出版年：2003
• 出版时间：2003
• 年：2003
• 卷：22
• 期：2/3
• 页码：129-143
• 全文大小：885 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  
• 出版者：Springer Netherlands
• ISSN：1573-7233

文摘

Membrane‐type 1 matrix metalloproteinase (MT1‐MMP) is an integral membrane proteinase that is frequently expressed in malignant cancer cells and has potent invasion‐promoting activity. When expressed on the cell surface, MT1‐MMP degrades the extracellular matrix (ECM) barrier adjacent to the cells to maintain the migration route to traverse the tissue. But MT1‐MMP is not just an enzyme that degrades ECM. MT1‐MMP also introduces limited cleavage into proteins at the cell‐ECM interspaces and converts their functions. The target molecules are ECM components, cell adhesion molecules, and latent forms of MMPs. Through these processing events MT1‐MMP modulates the migratory and invasive behavior of the cells.