Prognostic value of the DNMTs mRNA expression and genetic polymorphisms on the clinical outcome in oral cancer patients
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- 作者：Gordana Supic ; Ruzica Kozomara ; Katarina Zeljic…
- 关键词：Oral cancer ; DNMT1 ; DNMT3A ; DNMT3B ; mRNA ; Overexpression ; Polymorphism ; Overall survival ; Relapse ; free survival
- 刊名：Clinical Oral Investigations
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：21
- 期：1
- 页码：173-182
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Dentistry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1436-3771
- 卷排序：21
文摘
ObjectivesAlthough the importance of the epigenetic changes in tumors, including oral squamous cell carcinomas (OSCCs), is now becoming apparent, the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed. DNA methylation is regulated by a family of enzymes, DNA methyltransferases (DNMTs). DNMT gene expression analysis, as well as genetic polymorphisms, has not been previously evaluated in OSCC.