Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen
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- 作者：Gilda G. Hillman ; Lyndsey A. Reich…
- 关键词：MVA vector ; MUC1 ; IL ; 2 ; Radiation ; Renal Cell Carcinoma
- 刊名：Journal for ImmunoTherapy of Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：5
- 期：1
- 全文大小：2290KB
- 刊物主题：Oncology; Immunology;
- 出版者：BioMed Central
- ISSN：2051-1426
- 卷排序：5
文摘
BackgroundWe previously demonstrated that tumor irradiation potentiates cancer vaccines using genetic modification of tumor cells in murine tumor models. To investigate whether tumor irradiation augments the immune response to MUC1 tumor antigen, we have tested the efficacy of tumor irradiation combined with an MVA-MUC1-IL2 cancer vaccine (Transgene TG4010) for murine renal adenocarcinoma (Renca) cells transfected with MUC1.