Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma

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• 作者：Yoshiaki Kamikawa ; Yuji Kanmura…
• 关键词：Oral squamous cell carcinoma ; MUC1 ; MUC4 ; Immunohistochemistry ; Prognosis
• 刊名：International Journal of Clinical Oncology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：20
• 期：2
• 页码：298-307
• 全文大小：908 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Surgical Oncology
  Radiotherapy
  Diagnostic Radiology
  Internal Medicine
  Pathology
  
• 出版者：Springer Japan
• ISSN：1437-7772

文摘

Background Both MUC1 and MUC4 are high molecular weight glycoproteins and are independent indicators of worse prognosis in many human epithelial cancers including oral squamous cell carcinoma (OSCC). However, there has been no investigation of the clinical importance of the co-expression of MUC1 and MUC4 in OSCC. The aim of this study was to evaluate the co-expression profile of MUC1/MUC4 and analyze the prognostic significance in OSCC. Methods We examined the expression profile of MUC1 and MUC4 in OSCC tissues from 206 patients using immunohistochemistry. The co-expression profile of MUC1/MUC4 and its prognostic significance in OSCC was statistically analyzed. Results MUC1 and MUC4 overexpression were strongly correlated with each other (p?MUC1 and MUC4 expression was a powerful indicator for tumor aggressiveness such as tumor size (p?=?0.014), lymph node metastasis (0.0001), tumor stage (p?=?0.006), diffuse invasion (p?=?0.028), and vascular invasion (p?=?0.014). The MUC1/MUC4 double-positive patients showed the poorest overall and disease-free survival. Multivariate analysis revealed that MUC1/MUC4 double-positivity was the strong independent prognostic factor for overall and disease-free survival (p?=?0.007 and (p?=?0.0019), in addition to regional recurrence (p?=?0.0025). Conclusions Taken together, these observations indicate that the use of a combination of MUC1/MUC4 can predict outcomes for patients with OSCC. This combination is also a useful marker for predicting regional recurrence. MUC1 and MUC4 may be attractive targets for the selection of treatment methods in OSCC.