Geno- and Cyto-toxicity in Free-Living Rodent Mus spretus Exposed to Simulated Onshore Oil Spill

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• 作者：Flavio Manoel Rodrigues da Silva Júnior (1)
  Rita Isabel Monarca (2)
  Deodália Dias (2)
  Maria da Gra?a Ramalhinho (3)
  Maria da Luz Mathias (2)
  Ana Luíza Muccillo-Baisch (1)
  
• 关键词：Wild rodents ; Sentinels species ; Crude oil ; Sperm abnormality ; Comet assay ; Micronucleus test
• 刊名：Bulletin of Environmental Contamination and Toxicology
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：91
• 期：4
• 页码：465-468
• 全文大小：
• 作者单位：Flavio Manoel Rodrigues da Silva Júnior (1)
  Rita Isabel Monarca (2)
  Deodália Dias (2)
  Maria da Gra?a Ramalhinho (3)
  Maria da Luz Mathias (2)
  Ana Luíza Muccillo-Baisch (1)
  
  1. LEFT—Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande do Sul—FURG, Av. Itália, km 8, Campus Carreiros, Rio Grande, RS, CEP 96203-900, Brazil
  2. Centro de Estudos do Ambiente e Mar, Departamento de Biologia Animal, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisbon, Portugal
  3. Centro de Estudos do Ambiente e Mar, Museu Nacional de História Natural da Universidade de Lisboa, Rua da Escola Politécnica, 58, Lisbon, Portugal
  
• ISSN：1432-0800

文摘

This study investigated geno- and cyto-toxic damage in the free-living rodent, Mus spretus after exposure to a simulated spill of crude oil on soil. The results revealed increased mutagenicity and cytotoxicity in bone marrow cells and increased DNA damage in blood cells. Exposure to crude oil increased sperm abnormalities, with lasso-like folds being the most common. These results point to the value of this rodent in serving as a sentinel species for the monitoring and prediction of environmental hazards.