Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion
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- 作者：Ji Eun Kim ; Jun Go ; Ji Eun Sung ; Hyun Ah Lee ; Woo Bin Yun…
- 关键词：Constipation ; Uridine ; Loperamide ; Excretion parameters ; Mucin ; Muscarinic acetylcholine receptors
- 刊名：BMC Gastroenterology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：6057KB
- 刊物主题：Gastroenterology; Internal Medicine; Hepatology;
- 出版者：BioMed Central
- ISSN：1471-230X
- 卷排序：17
文摘
BackgroundUridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in constipation has yet to be established. Therefore, in this study, we investigated the laxative effects of Urd on chronic constipation.