Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
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- 作者：Muhammad Taha ; Nor Hadiani Ismail ; Waqas Jamil…
- 关键词：2 ; (2 ; methoxyphenyl) ; 5 ; phenyl ; 1 ; 3 ; 4 ; oxadiazole ; Antiglycation activity ; Rutin ; Diabetic
- 刊名：Medicinal Chemistry Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：25
- 期：2
- 页码：225-234
- 全文大小：1,674 KB
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Nor Hadiani Ismail (1) (2)
Waqas Jamil (3)
Syahrul Imran (1) (2)
Fazal Rahim (4)
Syed Muhammad Kashif (4)
Mohd Zulkefeli (1) (5)
1. Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia
2. Faculty of Applied Science, UiTM, 40450, Shah Alam, Selangor, Malaysia
3. Department of Chemistry, Hazara University, Mansehra, Pakistan
4. Institute of Advance Research Studies in Chemical Sciences, University of Sindh Jamshoro, Hyderabad, 76080, Pakistan
5. Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia - 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
- 出版者：Springer US
- ISSN：1554-8120
文摘
In the search of potent antidiabetic drug, we synthesized 1–25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1–25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1–6 and 8 showed potent activity ranging from 160.2 to 290.17 µM better than standard drug rutin (IC50 = 295.09 ± 1.04 µM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds.