Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

详细信息    查看全文

• 作者：Muhammad Waqas ; Shasha Zhang ; Zuhong He ; Mingliang Tang…
• 关键词：inner ear ; cochlea ; hair cell ; regeneration ; Wnt ; Notch ; signaling pathways
• 刊名：Frontiers of Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：10
• 期：3
• 页码：237-249
• 全文大小：411 KB
• 刊物主题：Medicine/Public Health, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：2095-0225
• 卷排序：10

文摘

Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.