Enantioselective Radical Reactions

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• 作者：Jake Zimmerman ; Mukund P. Sibi
• 关键词：Atom transfer ; Chiral Lewis acid ; Conjugate addition ; Enantioselective radical reactions ; Electron transfer
• 刊名：Topics in Current Chemistry
• 出版年：2006
• 出版时间：2006
• 年：2006
• 卷：263
• 期：1
• 页码：pp.107-162
• 全文大小：2,877 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Theoretical and Computational Chemistry
  Medicinal Chemistry
  Biochemistry
  Organometallic Chemistry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-5049

文摘

Over the past two decades, many researchers have been interested in “taming” the reactive free radical intermediate and utilizing it in enantioselective transformations. This review highlights the substantial progress made in this area of synthetic organic chemistry. The main classes of radical reactions that have received the most attention include atom transfer, conjugate addition, addition and trapping, and electron transfer reactions. Also, the possibility of establishing multiple stereocenters in one simple transformation makes enantioselective free radical chemistry a very attractive tool for organic chemists.