Sédation–analgésie avant procédure douloureuse chez l’enfant par association kétamine–propofol (kétofol) en camp de réfugiés

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• 作者：W. Caré ; C. Garcia ; P. Mornand ; V. Muller…
• 关键词：Sédation–analgésie avant procédure douloureuse ; Kétofol ; Kétamine ; Propofol ; Procedural sedation and analgesia ; Ketofol ; Ketamine ; Propofol
• 刊名：Annales fran?aises de médecine d'urgence
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：5
• 期：1
• 页码：16-22
• 全文大小：152 KB
• 参考文献：1. Vivien B, Adnet F, Bounes V, et al (2012) Sédation et analgésie en structure d’urgence. Réactualisation 2010 de la Conférence d’experts de la Sfar de 1999. Ann Fr Anesth Reanim 31:391-04
  2. Bounes V, groupe d’experts Sfar–SFMU (2012) Sédation et analgésie en structure d’urgence. Quelles sont les modalités de réalisation d’une sédation et/ou d’une analgésie pour des actes douloureux ? Ann Fr Anesth Reanim 31:340-
  3. Freysz M, Orliaguet G, groupe d’experts Sfar–SFMU (2012) Sédation et analgésie en structure d’urgence. Quels sont les propriétés et les inconvénients des produits utilisés ? Ann Fr Anesth Reanim 31:283-4 f="http://dx.doi.org/10.1016/j.annfar.2012.01.006" target="_blank" title="It opens in new window">CrossRef
  4. Mion G, Granry JC (2012) Utilisation de la kétamine lors de la réalisation de soins douloureux chez l’enfant. Arch Pediatr 19:1372- f="http://dx.doi.org/10.1016/j.arcped.2012.08.028" target="_blank" title="It opens in new window">CrossRef
  5. Chéron G, groupe d’experts Sfar–SFMU (2012) Sédation et analgésie en structure d’urgence. Pédiatrie: quelle sédation et analgésie chez l’enfant en ventilation spontanée ? Ann Fr Anesth Reanim 31:369-6
  6. Orliaguet G, groupe d’experts Sfar–SFMU (2012) Sédation et analgésie en structure d’urgence. Pédiatrie: quelle sédation et analgésie chez l’enfant ? Pharmacologie. Ann Fr Anesth Reanim 31:359-8
  7. Nolent P, Laudenbach V (2008) Sédation et analgésie en réanimation -Aspects pédiatriques. Ann Fr Anesth Reanim 27:623-2 f="http://dx.doi.org/10.1016/j.annfar.2008.04.014" target="_blank" title="It opens in new window">CrossRef
  8. Pacheco GS, Ferayorni A (2013) Pediatric procedural sedation and analgesia. Emerg Med Clin North Am 31:831-2 f="http://dx.doi.org/10.1016/j.emc.2013.04.002" target="_blank" title="It opens in new window">CrossRef
  9. Andolfatto G, Abu-Laban RB, Zed PJ, et al (2012) Ketamine–propofol combination (Ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med 59:504-2 f="http://dx.doi.org/10.1016/j.annemergmed.2012.01.017" target="_blank" title="It opens in new window">CrossRef
  10. Shah A, Mosdossy G, McLeod S, et al (2011) A blinded, randomized controlled trial to evaluate ketamine/propofol versus ketamine alone for procedural sedation in children. Ann Emerg Med 57:425-3 f="http://dx.doi.org/10.1016/j.annemergmed.2010.08.032" target="_blank" title="It opens in new window">CrossRef
  11. Shy BD, Strayer RJ, Howland MA (2013) Independent dosing of propofol and ketamine may improve procedural sedation compared with the combination Ketofol. Ann Emerg Med 61:257 f="http://dx.doi.org/10.1016/j.annemergmed.2012.07.130" target="_blank" title="It opens in new window">CrossRef
  12. Alletag MJ, Auerbach MA, Baum CR (2012) Ketamine, propofol, and ketofol use for paediatric sedation. Paediatr Emerg Care 28:1391- f="http://dx.doi.org/10.1097/PEC.0b013e318276fde2" target="_blank" title="It opens in new window">CrossRef
  13. Tosun Z, Esmaoglu A, Coruh A (2007) Propofol–ketamine vs propofol–fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes. Pediatr Anaesth 18:43-
  14. David H, Shipp J (2011) A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med 57:435-1 f="http://dx.doi.org/10.1016/j.annemergmed.2010.11.025" target="_blank" title="It opens in new window">CrossRef
  
• 刊物主题：Emergency Medicine; Anesthesiology; Intensive / Critical Care Medicine;
• 出版者：Springer Paris
• ISSN：2108-6591

文摘

Aim We aimed to estimate the efficacy and the tolerance of a combination of ketamine and propofol (ketofol) for procedural sedation and analgesia in children. Procedure An open cohort study was carried out in the Syrian refugee camp of Za’atari (Jordan) during summer 2013. The induction was composed of propofol (1 mg/kg) and ketamine (1 mg/kg) followed by a maintenance with propofol (4 mg/kg/hour). Boluses of propofol and/or ketamine were realized if needed. Results Ten procedural sedations were performed in 8 children (6 males and 2 females), with an average age of 4.5 ± 3.4 years (extremes: 2-2). The main indication was thermal burns (80%), for which the burnt body surface was always lower than 10%. Total administered drug doses were 3.5 ± 1.7 mg/kg (extremes: 1.8-.6) for the propofol and 1.4 ± 0.9 mg/kg (extremes: 1-.9) for the ketamine. The indicated procedure had always been realized in good conditions. The safety level was acceptable and no unexpected side effect was reported. Respiratory and cardiovascular depressions were mild and easily controlled. No serious event occurred. The recovery was quiet and good quality in all children. Conclusion Ketofol appears as an active and suitable combination for procedural sedation and analgesia in the management of burnt children. However, the procedure was time consuming and required the constant presence of 2 physicians, which fits more to a regulated activity.