Changes in the Levels of Serum-Soluble Interleukin-2 Receptor After Surgical Stress

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• 作者：Saburo Murakami ; Hideto Sakata ; Yoshitaka Tsuji ; Katsuhiko Okubo ; Takehiro Takahashi ; Masataka Kikuchi and Renzo Hirayama
• 关键词：Serum ; soluble interleukin ; 2 receptor ; Cytokine ; Surgical stress
• 刊名：Surgery Today
• 出版年：2003
• 出版时间：July 2003
• 年：2003
• 卷：33
• 期：8
• 页码：565-570
• 全文大小：176 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813

文摘

Purpose. Surgical stress induces alterations in numerous physiological functions, including the cell-mediated immune response. It is known that interleukin-2 receptor (IL-2R) is released from its specific affinity membrane receptor on activated T lymphocytes and then is detected as a form of the -chain of the IL-2R in the bloodstream. The levels of serum-soluble IL-2R (sIL-2R) reflect the quantity of activated T lymphocytes. This study investigated the changes in the serum sIL-2R levels and the relationship of such changes with other cytokines and the number of lymphocytes after abdominal surgery.Methods. Twenty-four patients who were scheduled to undergo abdominal operations were enrolled in this study. Blood samples of these cases were collected before surgery, and on postoperative days (POD) 1, 3, 7, and 14. The levels of serum sIL-2R were measured by an enzyme-linked immunosorbent assay.