Malignancy and hypercoagulability: a two-way association revisited

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• 作者：Elie G. Aoun ; Khaled M. Musallam ; Mohamad Abou-Ghazal and Ali T. Taher
• 关键词：Hypercoagulability ; Lung cancer ; Malignancy ; Stroke ; Thrombophilia ; Venous thromboembolism
• 刊名：Journal of Thrombosis and Thrombolysis
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：30
• 期：3
• 页码：340-341
• 全文大小：111.9 KB

文摘

Increasing evidence is highlighting the relationship between malignancy and hypercoagulability as a bidirectional association. We herein share our experience with a patient in whom such an association may be entertained. The patient, who had a history of venous thromboembolism, presented to our care with manifestation of stroke. Extensive workup revealed that the patient carries prothrombotic mutations in the prothrombin and methylenetetrahydrofolate reductase genes. The patient, a non-smoker, was also diagnosed with non-small cell lung carcinoma. The possible association between the patient’s malignancy and prothrombotic state are further discussed.