Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor

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• 作者：Suchitra D. Gopinath
• 关键词：Atrophy ; Soleus ; Tibialis anterior ; Myostatin ; p ; 70S6K ; p ; rpS6 ; p ; Stat3 ; Satellite cells ; Skeletal muscle
• 刊名：Skeletal Muscle
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：7
• 期：1
• 全文大小：2451KB
• 刊物主题：Cell Biology; Developmental Biology; Biochemistry, general; Systems Biology; Biotechnology;
• 出版者：BioMed Central
• ISSN：2044-5040
• 卷排序：7

文摘

BackgroundAlthough skeletal muscle wasting has long been observed as a clinical outcome of impaired vitamin D signaling, precise molecular mechanisms that mediate the loss of muscle mass in the absence of vitamin D signaling are less clear. To determine the molecular consequences of vitamin D signaling, we analyzed the role of signal transducer and activator of transcription 3 (Stat3) signaling, a known contributor to various muscle wasting pathologies, in skeletal muscles.