Effect of zinc supplementation on the distribution of various elements in the serum of diabetic rats subjected to an acute swimming exercise

详细信息    查看全文

• 作者：Mursel Bicer (1)
  Mustafa Akil (2)
  Abdullah Sivrikaya (3)
  Ersan Kara (2)
  Abdulkerim Kasim Baltaci (4)
  Rasim Mogulkoc (4)
  
• 关键词：Diabetes ; Exercise ; Zinc supplementation ; Elements ; Rat
• 刊名：Journal of Physiology and Biochemistry
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：67
• 期：4
• 页码：511-517
• 全文大小：118KB
• 参考文献：1. Akil M, Bicer M, Kilic M, Avunduk MC, Mogulkoc R, Baltaci AK (2011) Effect of intraperitoneal selenium administration on liver glycogen levels in rats subjected to acute forced swimming. Biol Trace Elem Res 139:341-46 CrossRef
  2. Al-Maroof RA, Al-Sharbatti SS (2006) Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J 27:344-50
  3. Bicer M, Gunay M, Akil M, Avunduk MC, Mogulkoc R, Baltaci AK (2011) Effect of long-term intraperitoneal zinc administration on liver glycogen levels in diabetic rats subjected to acute forced swimming. Biol Trace Elem Res 139:317-24 CrossRef
  4. Bideci A, Camurdan MO, Cinaz P, Dursun H, Demirel F (2005) Serum zinc, insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 18:1007-011 CrossRef
  5. Bolkent S, Bolkent S, Yanardag R, Mutlu O, Yildirim S (2006) Alterations in somatostatin cells and biochemical parameters following zinc supplementation in gastrointestinal tissue of streptozotocin-induced diabetic rats. Acta Histochem Cytochem 39:9-5 CrossRef
  6. Brandao-Neto J, Silva CAB, Rezende AA, Almeida MG, Sales VSP, Marchini JS (2003) Zinc pharmacokinetics in insülin-dependent diabetes mellitus patients after oral zinc tolerance test. Nutr Res 23:141-50 CrossRef
  7. Chausmer AB (1998) Zinc, insulin and diabetes. J Am Coll Nutr 17:109-15
  8. Chen MD, Liou SJ, Lin PY, Yang VC, Alexander PS, Lin WH (1998) Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese / (ob/ob) mice. Biol Trace Elem Res 61:303-11 CrossRef
  9. Cordova A (1994) Zinc content in selected tissues in streptozotocin-diabetic rats after maximal exercise. Biol Trace Elem Res 42:209-16 CrossRef
  10. Cordova A, Alvarez-Mon M (1995) Behaviour of zinc in physical exercise: a special reference to immunity and fatigue. Neurosci Biobehav Rev 19:439-45 CrossRef
  11. Cordova A, Gimenez M, Escanero JF (1990) Changes of plasma zinc and copper at various times of swimming until exhaustion in the rat. J Trace Elem Electrolytes Health Dis 4:189-92
  12. Dogukan A, Sahin N, Tuzcu M, Juturu V, Orhan C, Onderci M, Komorowski J, Sahin K (2009) The effects of chromium histidinate on mineral status of serum and tissue in fat-fed and streptozotocin-treated type II diabetic rats. Biol Trace Elem Res 131:124-32 CrossRef
  13. Duzguner V, Kaya S (2007) Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits. Free Radic Biol Med 42:1481-486 CrossRef
  14. Faure P, Roussel AM, Martinie M, Favier A, Halimi S (1991) Insulin sensitivity in zinc-depleted rat: assessment with the euglycaemic hyperinsulinemic clamp technique. Diabetes Metab 17:325-31
  15. Field M (1998) Nutritional factors adversely influencing the glucose/insulin system. J Am Coll Nutr 17:317-21
  16. Foster M, Samman S (2010) Zinc and redox signaling: perturbations associated with cardiovascular disease and diabetes mellitus. Antioxid Redox Signal 13:1549-573 CrossRef
  17. Fushimi H, Inoue T, Yamada Y, Horie H, Kameyama M, Minami T, Okazaki Y (1993) Zinc deficiency exaggerares diabetik osteoporosis. Diabetes Res Clin Pract 20:191-96 CrossRef
  18. Girish BN, Rajesh G, Vaidyanathan K, Balakrishnan V (2009) Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency. JOP 10:651-56
  19. Gleeson M, Nieman DC, Pedersen BK (2004) Exercise, nutrition and immune function. J Sports Sci (London) 22:115-25 CrossRef
  20. Harmer AR, Ruell PA, McKenna MJ, Chisholm DJ, Hunter SK, Thom JM, Morris NR, Flack JR (2006) Effects of sprint training on extrarenal potassium regulation with intense exercise in Type 1 diabetes. J Appl Physiol 100:26-4 CrossRef
  21. Havel PJ, Uriu-Hare JY, Liu T, Stanhope KL, Stern JS, Keen CL, Ahrén B (1998) Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Physiol 274:1482-491
  22. Jansen J, Karges W, Rink L (2009) Zinc and diabetes—clinical links and molecular mechanisms. J Nutr Biochem 20:399-17 CrossRef
  23. Khaled S, Brun JF, Bardet L, Cassanas G, Monnier JF, Orsetti A (1997) Importance physilogique du zinc dans l’activité physique. Sci Sports 12:179-91 CrossRef
  24. Kilic M (2007) Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc. Neuro Endocrinol Lett 28:681-85
  25. Laakso M (2001) Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention. J Intern Med 249:225-35 CrossRef
  26. Lukaski HC (1995) Micronutrients (magnesium, zinc, copper): are mineral supplementation needed for athletes. Int J Sport Nutr 5:74-3
  27. Lynch CJ, Patson BJ, Goodman SA, Trapolsi D, Kimball SR (2001) Zinc stimulates the activity of the insulin-and nutrient-regulated protein kinase mTOR. Am J Physiol 281:E25–E34
  28. Marrella M, Guerrini F, Solero PL, Tregnaghi PL, Schena F, Velo GP (1993) Blood copper and zinc changes in runners after a marathon. J Trace Elem Electrolytes Health Dis 7:248-50
  29. Patlar S, Boyali E, Baltaci AK, Mogulkoc R, Gunay M (2011) Elements in sera of elite taekwondo athletes: effects of vitamin E supplementation. Biol Trace Elem Res 139:119-25 CrossRef
  30. Patlar S, Boyali E, Baltaci AK, Mogulkoc R (2011) The effect of vitamin a supplementation on various elements in elite taekwondo players. Biol Trace Elem Res 139:296-00 CrossRef
  31. Rahimi R, Nikfar S, Larijani B, Abdollahi M (2005) A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 59:365-73 CrossRef
  32. Raz I, Karsai D, Katz M (1989) The influence of zinc supplementation on glucose homeostasis in NIDDM. Diabetes Res 11:73-9
  33. Rossetti L, Giaccari A, Klein-Robbenhaar E, Vogel LR (1990) Insulinomimetic properties of trace elements and characterization of their in vivo model of action. Diabetes 39:1243-250 CrossRef
  34. Shidfar F, Aghasi M, Vafa M, Heydari I, Hosseini S, Shidfar S (2010) Effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar, insulin, apoprotein B and apoprotein A-I in patients with type I diabetes. Int J Food Sci Nutr 61:182-91 CrossRef
  35. Shisheva A, Gefel D, Shechter Y (1992) Insulinlike effects of zinc ion in vitro and in vivo. Diabetes 41:982-88 CrossRef
  36. Simon S, Taylor CG (2001) Dietary zinc supplementation attenuates hyperglycemia in / db/db mice. Exp Biol Med 226:43-1
  37. Singh A, Failla ML, Deuster PA (1994) Exercise-induced changes in immune function: effects of zinc supplementation. J Appl Physiol 76:2298-303
  38. Tang Y, Yang Q, Lu J, Zhang X, Suen D, Tan Y, Jin L, Xiao J, Xie R, Rane M, Li X, Cai L (2010) Zinc supplementation partially prevents renal pathological changes in diabetic rats. J Nutr Biochem 21:237-46 CrossRef
  39. Tapiero H, Tew KD (2003) Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother 57:399-11 CrossRef
  40. Tobia MH, Zdanowicz MM, Wingertzhan MA, McHeffey-Atkinson B, Slonim AE, Wapnir RA (1998) The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wistar rat. Mol Genet Metab 63:205-13 CrossRef
  41. Wu Y, Sun Z, Che S, Chang H (2004) Effects of zinc and selenium on the disorders of blood glucose and lipid metabolism and its molecular mechanism in diabetic rats. Wei Sheng Yan Jiu 33:70-3
  
• 作者单位：Mursel Bicer (1)
  Mustafa Akil (2)
  Abdullah Sivrikaya (3)
  Ersan Kara (2)
  Abdulkerim Kasim Baltaci (4)
  Rasim Mogulkoc (4)
  
  1. High School of Physical Education and Sport, Selcuk University, Konya, Turkey
  2. Hasan Dogan High School of Physical Education and Sports, Karabuk University, Karabuk, Turkey
  3. Selcuklu Medical School, Department of Biochemistry, Selcuk University, Konya, Turkey
  4. Selcuklu Medical School, Department of Physiology, Selcuk University, 42031, Konya, Turkey
  
• ISSN：1877-8755

文摘

The present study aims to examine the effect of supplementation of zinc on the distribution of various elements in the sera of diabetic rats subjected to an acute swimming exercise. A total of 80 Sprague–Dawley-type adult male rats were equally allocated to one of eight groups: Group 1, general; Group 2, zinc-supplemented; Group 3, zinc-supplemented diabetic; Group 4, swimming control; Group 5, zinc-supplemented swimming; Group 6, zinc-supplemented diabetic swimming; Group 7, diabetic swimming; and Group 8, diabetes. The rats were injected with 40?mg/kg/day subcutaneous streptozotocin (STZ) twice, with a 24-h interval between two injections. Zinc was supplemented at a dose of 6?mg/kg/day (ip) for 4?weeks. Blood samples were collected at the end of the 4-week study, and serum levels of lead, cobalt, molybdenum, chrome, sulfur, magnesium, manganese, sodium, potassium, phosphorus, copper, iron, calcium, zinc, and selenium (mg/L) were determined with atomic emission. The lowest molybdenum, chrome, copper, iron, potassium, magnesium, sodium, phosphorus, lead, selenium, and zinc values were obtained in Group 7 and 8. These same parameters were higher in the swimming exercise group (Group 4), relative to all other groups. The values in zinc-supplemented groups were found lower than the values in Group 4, but higher than those in Group 6 and 7. The results obtained from the study demonstrate that acute swimming exercise and diabetes affect the distribution of various elements in the serum, while zinc supplementation can prevent the negative conditions associated with both exercise and diabetes.