Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549–BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification

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• 作者：Midea Gierke ; Jan Sperveslage ; David Schwab…
• 关键词：Glioma ; Classification ; BRAF V600E ; KIAA1549–BRAF ; IDH1
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：142
• 期：1
• 页码：89-100
• 全文大小：820 KB
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• 作者单位：Midea Gierke (1)
  Jan Sperveslage (2)
  David Schwab (1)
  Rudi Beschorner (1)
  Martin Ebinger (3)
  Martin U. Schuhmann (4)
  Jens Schittenhelm (1)
  
  1. Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, Calwerstr. 3, 72076, Tübingen, Germany
  2. Department of Pathology, University of Tübingen, Tübingen, Germany
  3. Pediatric Oncology, University Childrens Hospital, University of Tübingen, Tübingen, Germany
  4. Department of Neurosurgery, University of Tuebingen, Tübingen, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335

文摘

Objective Gliomas are the leading cause of cancer-related morbidity in children and comprise a clinical, histological and molecular heterogenous group of CNS tumors. Appropriate treatment of these tumors relies on correct classification into tumor types and malignancy grades.