Immunolocalization of vascular endothelial growth factor in rat condylar cartilage during postnatal development

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• 作者：Junko Aoyama ; Eiji Tanaka ; Mutsumi Miyauchi ; Takashi Takata ; Koichi Hanaoka ; Yukiko Hattori ; Akiko Sasaki ; Mineo Watanabe and Kazuo Tanne
• 关键词：Vascular endothelial growth factor ; Temporomandibular joint ; Condylar cartilage
• 刊名：Histochemistry and Cell Biology
• 出版年：2004
• 出版时间：July 2004
• 年：2004
• 卷：122
• 期：1
• 页码：35-40
• 全文大小：458 KB

文摘

It is well known that angiogenesis is essential for the replacement of cartilage by bone during skeletal growth and regeneration. To address angiogenesis of endochondral ossification in the condyle, we examined the appearance of vascular endothelial growth factor (VEGF) and its receptor Flt-1 in condylar cartilage of the growing rat. The early expression of VEGF at various sites during condylar cartilage development indicates that VEGF plays a role in the regulation of angiogenesis at each site of bone formation. From the findings of Flt-1 immunoreactivity, the VEGF produced by the chondrocytes of the hypertrophic zone should contribute to the promotion of endothelial cell proliferation and to stimulate migration and activation of osteoclasts in condylar cartilage, resulting in the invasion of these cells into the mineralized zone.