Increased risk for colorectal adenomas and cancer in mono-allelic MUTYH mutation carriers: results from a cohort of North-African Jews

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• 作者：Guy Rosner ; Dani Bercovich ; Yael Etzion Daniel ; Hana Strul…
• 关键词：Adenomas ; APC ; negative adenomatous polyps ; Colorectal cancer ; North ; African Jews ; MUTYH ; Carriers
• 刊名：Familial Cancer
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：14
• 期：3
• 页码：427-436
• 全文大小：477 KB
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  25.Rosner G, Rozen
• 作者单位：Guy Rosner (1) (4)
  Dani Bercovich (2) (3)
  Yael Etzion Daniel (1)
  Hana Strul (1) (4)
  Naomi Fliss-Isakov (1) (4)
  Meirav Ben-Yehoiada (1)
  Erwin Santo (1) (4)
  Zamir Halpern (1) (4)
  Revital Kariv (1) (4)
  
  1. Departmant of Gastroenterology, Tel-Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel
  4. Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
  2. Human Molecular Genetics and Pharmacogenetics, Migal - Galilee Bio-Technology Center, Kiryat-Shmona, Israel
  3. Tel-Hai Academic College, Kiryat-Shmona, Israel
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Human Genetics
  Epidemiology
  
• 出版者：Springer Netherlands
• ISSN：1573-7292

文摘

Bi-allelic MUTYH gene mutations are associated with a clinical phenotype of multiple colorectal adenomas and an increased risk for colorectal cancer (CRC). It is unclear whether mono-allelic MUTYH gene carriers (heterozygotes) are also at increased risk for even few adenomas or cancer. In order to clarify an association between MUTYH heterozygotes and adenomas, we evaluated the frequency and types of MUTYH mutations and variants in 72 North-African Jews having few (?) colorectal adenomas with or without early onset (<50 years) CRC compared to 29 healthy controls. Germ-line DNA was analyzed for a panel of 6 MUTYH mutations and variants, and Sanger sequencing of the entire MUTYH gene was performed for mono-allelic MUTYH mutation carriers. APC gene mutations and Lynch syndrome were excluded in the relevant cases according to accepted clinical criteria. Twenty-two of the 72 adenoma subjects (30.5 %) had MUTYH mutations or variants. Nine were homozygotes or compound heterozygotes: all had >10 adenomas and one had CRC. Thirteen others were mono-allelic carriers (heterozygotes) of a single MUTYH mutation: six had more than ten adenomas and seven had less than ten adenomas; of these 13 mono-allelic carriers, six had a neoplasm: three CRCs and three extra-intestinal tumors. Eleven of the thirteen mono-allelic carriers with adenomas had a family history of cancer in first or second degree relatives. A multivariable model showed positive correlation between G396D, Y179C and 1186 ins GG mutations and number of adenomas (OR 8.6, 10.2 and 14.4, respectively). The Q324H variant was negatively associated with the number of adenomatous polyps (OR ?.23). In conclusion, MUTYH mutations are prevalent among Jews of North-African origin with colorectal adenomas with or without early onset CRC. Mono-allelic MUTYH carriers with a family history of cancer had a clinical phenotype that varied from having only few adenomas to multiple (>10) adenomas. These findings support MUTYH testing in patients with even few adenomas and suggest the consideration of increased surveillance in mono-allelic carriers with a family history of cancer. Keywords Adenomas APC-negative adenomatous polyps Colorectal cancer North-African Jews MUTYH Carriers