Non-neuronal cholinergic activity is potentiated in myasthenia gravis
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- 作者：Bin Han ; Chao Zhang ; Shoufeng Liu ; Yiping Xia ; Hao Sun ; Zhongying Gong…
- 关键词：Acetylcholine ; Myasthenia gravis ; Inflammation ; Cholinergic anti ; inflammatory pathway
- 刊名：BMC Neurology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：905KB
- 刊物主题：Neurology; Neurochemistry; Neurosurgery;
- 出版者：BioMed Central
- ISSN：1471-2377
- 卷排序：17
文摘
BackgroundNon–neuronal acetylcholine (ACh) restricts autoimmune responses and attenuates inflammation by cholinergic anti-inflammation pathway. To date, the implication of ACh in myasthenia gravis (MG) remained unexplored. This study aimed to investigate the possible relationship between ACh levels, anti–muscle-specific tyrosine kinase (MuSK) antibody titers, main clinical features and outcomes of MG patients.