Xenopus Nerve-Muscle Cultures: a Novel Cell-Based Assay for Serological Diagnosis and Pathological Research of Myasthenia Gravis
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- 作者：Zora Chui Kuen Chan ; Marilyn Janice Oentaryo ; Chi Wai Lee
- 关键词：Xenopus ; Tissue culture ; Neuromuscular junction ; Acetylcholine receptor ; Myasthenia gravis ; Cell ; based assay
- 刊名：Current Pathobiology Reports
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：5
- 期：1
- 页码：57-65
- 全文大小：
- 刊物主题：Pathology;
- 出版者：Springer US
- ISSN：2167-485X
- 卷排序：5
文摘
Purpose of ReviewAt present, the most common diagnostic measures for the autoimmune neuromuscular disease myasthenia gravis (MG) are radioimmunoprecipitation assay (RIPA), enzyme-linked immunosorbent assay (ELISA), and cell-based assay (CBA). Considering the pitfalls of these diagnostic assays, this review describes the advantages of using Xenopus tissue cultures for MG diagnosis and research.