Effects of Different Carbon Sources on Growth, Membrane Permeability, β-Sitosterol Consumption, Androstadienedione and Androstenedione Production by Mycobacterium neoaurum

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• 作者：Yanli Yin
• 关键词：Carbon sources ; Membrane permeability ; 1 ; 4 ; Androstadiene ; 3 ; 17 ; dione ; 4 ; Androstene ; 3 ; 17 ; dione ; Mycobacterium neoaurum
• 刊名：Interdisciplinary Sciences: Computational Life Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：8
• 期：1
• 页码：102-107
• 全文大小：835 KB
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• 作者单位：Yanli Yin (1)
  
  1. College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, China
  
• 刊物主题：Computer Appl. in Life Sciences; Computational Biology/Bioinformatics; Statistics for Life Sciences, Medicine, Health Sciences; Theoretical and Computational Chemistry; Theoretical, Mathematical and Computational Physics; Computational Science and Engineering;
• 出版者：International Association of Scientists in the Interdisciplinary Areas
• ISSN：1867-1462

文摘

Effects of different carbon sources on growth, membrane permeability, β-sitosterol consumption, androstadienedione and androstenedione (AD(D)) production by Mycobacterium neoaurum were investigated. The results indicated that glucose was advantageous to the growth and resulted in the adverse effects on the phytosterols consumption and AD(D) production compared to the results of propanol and isopropanol as sole carbon source. The cell wall widths of 9.76 by propanol and 8.00 nm by isopropanol were 38.3 and 49.4 % thinner than that of 15.82 nm by glucose, respectively. The partition coefficient of the cell grown in propanol and isopropanol was 18.1 and 22.2, which were 7.23- and 9.09-fold higher than that of the cell grown in glucose. Keywords Carbon sources Membrane permeability 1,4-Androstadiene-3,17-dione 4-Androstene-3,17-dione Mycobacterium neoaurum