Effects of Sibutramine on Gastric Emptying, Intestinal Motility and Rectal Tone in Dogs

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• 作者：Junying Xu and Jiande DZ Chen
• 关键词：Gastric emptying ; Small ; bowel contraction ; Appetite ; Food intake ; Gastrointestinal motility
• 刊名：Digestive Diseases and Sciences
• 出版年：2008
• 出版时间：January, 2008
• 年：2008
• 卷：53
• 期：1
• 页码：155-162
• 全文大小：241.2 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

The aim of this study was to evaluate the effects of sibutramine on gastric emptying, small-bowel contractions, rectal tone and compliance, and gastrointestinal myoelectrical activity. The study was performed in 14 dogs. It was composed of three separate experiments: gastric emptying of liquids and gastrointestinal slow waves; small-bowel contractions; and rectal tone and rectal compliance. Each experiment included two sessions: a control session and a treatment session with sibutramine (5 mg/kg orally) administrated 2 h before the study. Sibutramine significantly accelerated liquid gastric emptying at 75 and 90 min after the meal but did not alter gastrointestinal slow waves. Gastric emptying at 75 and 90 min was 61.42 ± 7.71 and 66.32 ± 7.67% in the control session, and increased to 71.27 ± 5.14 and 75.93 ± 5.29% in the session with sibutramine (p < 0.05, vs. control). Sibutramine significantly inhibited postprandial small-bowel contractions. Sibutramine did not alter the rectal tone, but significantly increased rectal compliance. Sibutramine accelerates gastric emptying of liquids but inhibits small-bowel contractions. These findings suggest the peripheral mechanisms of sibutramine in reducing food intake and causing weight loss in obesity patients.