How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression?

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• 作者：Elizabeth Ferreira Martinez…
• 关键词：Myoepithelial cells ; In situ condition ; Carcinoma ex ; pleomorphic adenoma
• 刊名：Journal of Cell Communication and Signaling
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：9
• 期：3
• 页码：279-280
• 全文大小：192 KB
• 参考文献：Altemani A, Martins MT, Freitas L, Soares F, Ara煤jo NS, Ara煤jo VC (2005) Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology 46:635鈥?41
  Aoki Y, Jaffe ES, Chang Y, Jones K, Teruya-Feldstein J, Moore PS, Tosato G (1999) Angiogenesis and hematopoiesis induced by Kaposi鈥檚 sarcoma-associated herpesvirus-encoded interleukin-6. Blood 93:4034鈥?043PubMed
  Ara煤jo VC, Altemani A, Furuse C, Martins MT, de Ara煤jo NS (2006) Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol 42:1011鈥?016CrossRef PubMed
  Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG, Goldberg AF, Pestell RG, Howell A, Sneddon S, Birbe R, Tsirigos A, Martinez-Outschoorn U, Sotgia F, Lisanti MP (2012) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 11:2285鈥?302PubMed Central CrossRef PubMed
  Jee SH, Shen SC, Chiu HC, Tsai WL, Kuo ML (2001) Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency. Oncogene 20:198鈥?08CrossRef PubMed
  Kinoshita T, Ito H, Miki C (1999) Serum interleukin-6 level reflects the tumor proliferative activity in patients with colorectal carcinoma. Cancer 85:2526鈥?531CrossRef PubMed
  Martinez EF, Demasi AP, Miguita L, Altemani A, Ara煤jo NS, Ara煤jo VC (2010) FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. Oncol Rep 24:155鈥?60CrossRef PubMed
  Martinez EF, Demasi AP, Napimoga MH, Arana-Chavez VE, Altemani A, de Ara煤jo NS, de Ara煤jo VC (2012a) In vitro influence of the extracellular matrix in myoepithelial cells stimulated by malignant conditioned medium. Oral Oncol 48:102鈥?09CrossRef PubMed
  Martinez EF, Montaldi PT, de Ara煤jo NS, Altemani A, de Ara煤jo VC (2012b) A proposal of an in vitro model which mimics in situ areas of carcinoma. J Cell Commun Signal 6:107鈥?09PubMed Central CrossRef PubMed
  Martinez EF, Napimoga MH, Montalli VA, de Ara煤jo NS, de Ara煤jo VC (2013) In vitro cytokine expression in in situ-like areas of malignant neoplasia. Arch Oral Biol 58:552鈥?57CrossRef PubMed
  Silva CA, Martinez EF, Demasi AP, Altemani A, da Silveira Bossonaro JP, Ara煤jo NS, de Ara煤jo VC (2015) Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model. J Cell Commun Signal
  Zacarias-Fluck MF, Morancho B, Vicario R, Luque Garcia A, Escorihuela M, Villanueva J, Rubio IT, Arribas J (2015) Effect of cellular senescence on the growth of HER2-positive breast cancers. J Natl Cancer Inst 13:107(5)
  
• 作者单位：Elizabeth Ferreira Martinez (1)
  Ney Soares de Ara煤jo (1)
  Vera Cavalcanti de Ara煤jo (1)
  
  1. Department of Oral Pathology, S茫o Leopoldo Mandic Institute and Research Center, Rua Jos茅 Rocha Junqueira 13, Ponte Preta, 13045-755, Campinas, Brazil
  
• 刊物主题：Cell Biology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1873-961X

文摘

In this brief commentary, we have shown how the benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma from salivary gland can favor tumor progression, not only dying by autophagy/senescence phenomena, disrupting the physical barrier, but also providing fuel for tumor progression. Keywords Myoepithelial cells In situ condition Carcinoma ex-pleomorphic adenoma