Immunohistochemical localization of keratin 5 in the submandibular gland in adult and postnatal developing mice

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• 作者：Miyuki Yamamoto ; Hiroki Nakata ; Tewarat Kumchantuek…
• 关键词：Duct system ; Keratin 5 ; Myoepithelial cells ; Progenitor cells ; Postnatal development ; Submandibular gland
• 刊名：Histochemistry and Cell Biology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：145
• 期：3
• 页码：327-339
• 全文大小：3,330 KB
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• 作者单位：Miyuki Yamamoto (1)
  Hiroki Nakata (1)
  Tewarat Kumchantuek (1) (2)
  Natthiya Sakulsak (1) (2)
  Shoichi Iseki (1)
  
  1. Department of Histology and Embryology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-8640, Japan
  2. Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anatomy
  Medicine/Public Health, general
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-119X

文摘

Keratin 5 (K5) is a marker of basal progenitor cells in the epithelia of a number of organs. During prenatal development of the submandibular gland (SMG) in mice, K5+ progenitor cells in the developing epithelia play important roles in its organogenesis. Although K5+ cells are also present in the adult mouse SMG and may function in tissue regeneration, their histological localization has not yet investigated in detail. In the present study, we examined the immunohistochemical localization of K5 in the SMG in adult and postnatal developing mice. At birth, K5 immunoreactivity was detected in the entire duct system, in which it was localized in the basal cells of a double-layered epithelium, but was not detected in the terminal tubule or myoepithelial cells. At postnatal weeks 1–3, with the development of intercalated ducts (ID), striated ducts (SD), and excretory ducts (ED), K5-immunoreactive basal cells were gradually restricted to the ED and the proximal double-layered portions of the ID connecting to the SD. At the same time, K5 immunoreactivity appeared in myoepithelial cells, in which its positive ratio gradually increased. In adults, K5 immunoreactivity was localized to most myoepithelial cells, most basal cells in the ED, and a small number of ID cells at the boundary between the ID and SD in the female SMG or between the ID and granular convoluted tubules in the male SMG. These results suggest that K5 is a marker of differentiated myoepithelial cells and duct progenitor cells in the mouse SMG.