Myofibroblasts and inflammatory cells as players of cardiac fibrosis
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- 作者：Hitoshi Kurose ; Supachoke Mangmool
- 关键词：Myofibroblasts ; Inflammation ; Myocardial infarction ; Cardiac fibrosis ; Signaling molecules
- 刊名：Archives of Pharmacal Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：39
- 期：8
- 页码：1100-1113
- 全文大小：692 KB
- 刊物主题：Pharmacy; Pharmacology/Toxicology;
- 出版者：Springer Netherlands
- ISSN：1976-3786
- 卷排序：39
文摘
On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate inflammatory responses that play important roles in cardiac remodeling including fibrosis. Fibrosis is an excess accumulation of extracellular collagen. Currently, drugs used to treat cardiac fibrosis are not commercially available. Myofibroblasts are responsible for the production and secretion of collagen. Infiltrating inflammatory cells interact with fibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities of myofibroblasts. Regulation of collagen production is critical for modulating the progression of fibrosis. Hence, the manipulation of activities of inflammatory cells and myofibroblasts will provide promising therapeutic targets for treatment of cardiac fibrosis.