Kardiales Remodelling nach Myokardinfarkt

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• 作者：Prof. Dr. med. G. Ertl ; S. Brenner ; C. E. Angermann
• 关键词：SchlüsselwörterMyokardinfarkt ; Kardiales Remodelling ; Prognose ; Herzinsuffizienz ; Therapie
• 刊名：Herz
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：42
• 期：1
• 页码：107-120
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Cardiology; Internal Medicine;
• 出版者：Springer Medizin
• ISSN：1615-6692
• 卷排序：42

文摘

Heart failure remains a frequent cause of death and is the leading reason for hospitalization in Germany although therapeutic options have significantly increased over the past years particularly in heart failure with reduced ejection fraction. Clinical symptoms are usually preceded by cardiac remodeling, which was originally defined only by left ventricular dilatation and depressed function but is also associated with typical cellular and molecular processes. Healing after acute myocardial infarction is characterized by inflammation, cellular migration and scar formation. Cardiac remodeling is accompanied by adaptive changes of the peripheral cardiovascular system. Since prevention is the primary goal, rapid diagnosis and treatment of myocardial infarction are mandatory. Early reperfusion therapy limits infarct size and enables the best possible preservation of left ventricular function. Standard pharmacotherapy includes angiotensin-converting enzyme inhibitors, angiotensin-1-receptor blockers and beta blockers. In addition, mineralocorticoid receptor antagonists have proven beneficial. Compounds specifically targeting infarct healing processes are currently under development.