Effects of high glucose on human umbilical vein endothelial cell permeability and myosin light chain phosphorylation
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- 作者：Xiao-Yan Zhao ; Xiao-Fang Wang ; Ling Li ; Li Zhang…
- 关键词：Human umbilical vein endothelial cell ; Permeability ; Myosin light chain ; High glucose ; RhoA/ROCK pathway
- 刊名：Diabetology and Metabolic Syndrome
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：7
- 期：1
- 全文大小：973 KB
- 刊物主题：Diabetes; Metabolic Diseases; Endocrinology;
- 出版者：BioMed Central
- ISSN：1758-5996
文摘
Background Diabetes mellitus is one of the most important risk factors for atherosclerosis. However, the mechanisms underlying high-glucose-induced atherosclerosis remain unclear. This study was designed to observe the effects of high-glucose stimulation on the permeability of cultured human umbilical vein endothelial cells (HUVECs), and to explore the effects of RhoA–Rho-associated protein kinase (ROCK) signal transduction pathway activation and myosin light chain (MLC) phosphorylation.