Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea

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• 作者：Ae-Ra Lee (6)
  Jinwoo Lee (6)
  Sun-Mi Choi (6)
  Moon-Woo Seong (7)
  Sung A Kim (6)
  Myoungsil Kim (6)
  Kyung Ok Chae (6)
  Ji Sun Lee (6)
  Jae-Joon Yim (6)
  
• 关键词：Bronchiectasis ; Clinical characteristics ; Immunopathogenesis ; Nontuberculous mycobacterial lung disease ; Phenotype
• 刊名：BMC Infectious Diseases
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：173 KB
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  25. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/558/prepub
  
• 作者单位：Ae-Ra Lee (6)
  Jinwoo Lee (6)
  Sun-Mi Choi (6)
  Moon-Woo Seong (7)
  Sung A Kim (6)
  Myoungsil Kim (6)
  Kyung Ok Chae (6)
  Ji Sun Lee (6)
  Jae-Joon Yim (6)
  
  6. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea
  7. Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea
  
• ISSN：1471-2334

文摘

Background This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients. Methods We prospectively recruited patients between 20 and 80?years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients. Results A total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients. Conclusions Significant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE. Trial registration information ClinicalTrials.gov Registration number; NCT01616745