Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice

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• 作者：Soojeong Jang (1) (2)
  Yunsook Lim (3)
  Giuseppe Valacchi (3) (4)
  Sungbin Sorn (5)
  Hyon Park (6)
  Na-Young Park (3)
  Myoungsook Lee (1) (7)
  
• 关键词：Ginsenosides ; Apoptosis ; Apo E KO mice ; LPO ; NFκB ; MAPK ; Caspase ; Cleaved PARP ; Bcl ; 2 ; Hyperlipidemia
• 刊名：Genes & Nutrition
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：7
• 期：2
• 页码：319-329
• 全文大小：543KB
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• 作者单位：Soojeong Jang (1) (2)
  Yunsook Lim (3)
  Giuseppe Valacchi (3) (4)
  Sungbin Sorn (5)
  Hyon Park (6)
  Na-Young Park (3)
  Myoungsook Lee (1) (7)
  
  1. Department of Food and Nutrition, Nutrition Biochem Lab, Sungshin Women’s University, #249-1, 3-ga, Dongsun-dong, Sungbuk-ku, Seoul, 136-742, Republic of Korea
  2. Korean Food Research Institute, Sungnam, Gyeonggi-do, Republic of Korea
  3. Department of Food and Nutrition, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea
  4. Department of Biomedical Sciences, University of Siena, 53100, Siena, Italy
  5. Department of Biological Sciences, College of Life Science and Bioengineering, Korea Advanced Institute of Science and Technology, Daejeon city, Republic of Korea
  6. Department of Sport Medicine, College of Physical Education, Kyung Hee University, Yongin, Republic of Korea
  7. Research Institute of Obesity Science, Sungshin Women’s University, Seoul, Republic of Korea
  
• ISSN：1865-3499

文摘

Ginsenosides, bioactive compounds of Panax Ginseng C.A. Meyer, are divided into protopanaxadiol (PD) and protopanaxtriol (PT). The aim of this study was to evaluate the protective effects of different PD and PT combination ratios on liver inflammation and apoptosis in hyperlipidemic apo E KO mice. R1 (PD/PT?=?1, high Rg1 and Rb1) and R2 (PD/PT?=?2, high Re and Rd) extracts were intraperitoneally injected by 100?mg/kg/day at the 8th week. R1 and R2 improved atherogenic indices by increasing HDL and lowering total cholesterol (TC) and triacylglyceride (TG) selectively. R1 decreased lipid peroxides (LPO) level in plasma and liver tissue of hyperlipidemic mice, and R2 lowered plasma malondialdehyde(MDA) level. R1 and R2 not only regulated the expression of cyclooxygenase (COX)-2, IκB-α, phopho-ERK 1/2, and phopho-SAPK/JNK levels but also were significantly effective in blocking apoptotic signals, such as caspase-8, -9, as well as the cleavage of PARP in liver. Different combinational treatment of PD and PT extracts might ameliorate the liver inflammation and apoptosis in hyperlipidemic apo E KO mice, which is atherosclerotic animal model.