Cholesterol ester transfer protein gene is associated with high-density lipoprotein cholesterol levels in Korean population

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• 作者：Jae Woong Sull (1)
  Jong-Eun Lee (2)
  Myoungsook Lee (3)
  Sun Ha Jee (4)
  
• 关键词：HDL ; cholesterol ; CETP ; Polymorphisms
• 刊名：Genes & Genomics
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：34
• 期：2
• 页码：231-235
• 全文大小：253KB
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• 作者单位：Jae Woong Sull (1)
  Jong-Eun Lee (2)
  Myoungsook Lee (3)
  Sun Ha Jee (4)
  
  1. Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Seongnam, Korea
  2. DNA Link, Inc., Seoul, Korea
  3. Department of Food and Nutrition, Sungshin Women’s University, Seoul, Korea
  4. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
  

文摘

High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated cholesterol ester transfer protein (CETP) as possibly causal. We tested for the association between single nucleotide polymorphisms (SNPs) in CETP gene and HDL cholesterol levels in Korean population. A total of 979 subjects in Seoul City were genotyped using a genome-wide marker panel for a discovery study. Another 2,277 subjects in Bundang-Gu in Korea were used for a replication study with selected markers. In the discovery phase, the top SNP associated with mean HDL cholesterol levels was rs6499861 in the CETP gene on chromosome 16 (p=1.18×10? in the Seoul City sample, p=8.91×10? in the Bundang-Gu sample). Another SNP (rs6499863) in the CETP gene was also among the top five SNPs associated with HDL cholesterol levels (p=3.83×10? in the Seoul City sample, p=3.29×10? in the Bundang-Gu sample). SNP rs1800775 was also associated with HDL cholesterol levels (p=4.86×10? in meta-analysis results of 3256 samples). This study clearly demonstrates that genetic variants in CETP influence HDL cholesterol levels in Korean adults.