Peroxisome Proliferator-Activated Receptor γ and Retinoic Acid Receptor Synergistically Up-Regulate the Tumor Suppressor PTEN in Human Promyeloid Leukemia Cells
详细信息 查看全文
- 作者：Young-Rae Lee (1)
Hong-Nu Yu (1)
Eun-Mi Noh (1)
Jong-Suk Kim (1)
Eun-Kyung Song (1)
Myung-Kwan Han (2)
Byeong-Soo Kim (3)
Sung-Ho Lee (3)
Jinny Parkd (4) - 关键词：PPARγ ; RAR ; PTEN ; HL ; 60
- 刊名：International Journal of Hematology
- 出版年：2007
- 出版时间：April 2007
- 年：2007
- 卷：85
- 期：3
- 页码：231-237
- 全文大小：304KB
- 参考文献：1. Barbui T, Finazzi G, Falanga A. The impact of all-trans-retinoic acid on the coagulopathy of acute promyelocytic leukemia. / Blood. 1998;91:3093-102.
2. Rosen ED, Spiegelman BM. PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth. / J Biol Chem. 2001;276:37731- 37734. CrossRef
3. Konopleva M, Andreeff M. Role of peroxisome proliferator-activated receptor-γ in hematologic malignancies. / Curr Opin Hematol. 2002;9:294-02. CrossRef
4. Koeffler HP. Peroxisome proliferator-activated receptor γ and cancers. / Clin Cancer Res. 2003;9:1-.
5. Szanto A, Nagy L. Retinoids potentiate peroxisome proliferator-activated receptor γ action in differentiation, gene expression, and lipid metabolic processes in developing myeloid cells. / Mol Pharmacol. 2005;67:1935-943. CrossRef
6. Yasugi E, Horiuchi A, Uemura I, et al. Peroxisome proliferator-activated receptor γ ligands stimulate myeloid differentiation and lipogenesis in human leukemia NB4 cells. / Dev Growth Differ. 2006;48:177-88. CrossRef
7. Breitman TR, Selonick SE, Collins SJ. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. / Proc Natl Acad Sci U S A. 1980;77:2936-940. CrossRef
8. Hirase N, Yanase T, Mu Y, et al. Thiazolidinedione induces apoptosis and monocytic differentiation in the promyelocytic leukemia cell line HL60. / Oncology. 1999;57(suppl 2):17-6. CrossRef
9. Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. / Proc Natl Acad Sci U S A. 1998;95:13513-3518. CrossRef
10. Wen S, Stolarov J, Myers MP, et al. PTEN controls tumor-induced angiogenesis. / Proc Natl Acad Sci U S A.2001;98:4622-627. CrossRef
11. Kim JS, Peng X, De PK, Geahlen RL, Durden DL. PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac. / Blood. 2002;99:694-97. CrossRef
12. Patel L, Pass I, Coxon P, Downes CP, Smith SA, Macphee CH.Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN. / Curr Biol. 2001;11:764-68. CrossRef
13. Kim KY, Kim SS, Cheon HG. Differential anti-proliferative actions of peroxisome proliferator-activated receptor-γ agonists in MCF-7 breast cancer cells. / Biochem Pharmacol. 2006;72:530-40. CrossRef
14. Kwak YG, Song CH, Yi HK, et al. Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. / J Clin Invest. 2003;111:1083-092.
15. Hwang PH, Yi HK, Kim DS, Nam SY, Kim JS, Lee DY Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene. / Cancer Lett. 2001;172:83-1. CrossRef
16. Cappellini A, Tabellini G, Zweyer M, et al. The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27Kip1 and control of cyclin D1 expression. / Leukemia. 2003;17:2157-167. CrossRef
17. Seminario MC, Precht P, Wersto RP, Gorospe M, Wange RL. PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. / Oncogene. 2003;22:8195-204. CrossRef
18. Moon SK, Kim HM, Kim CH. PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-κB and AP-1 in vascular smooth muscle cells. / Arch Biochem Biophys. 2004;421:267-76. CrossRef
19. Weng LP, Smith WM, Dahia PL, et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. / Cancer Res. 1999;59:5808-814.
20. Weng LP, Gimm O, Kum JB, et al. Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. / Hum Mol Genet. 2001;10:251-58. CrossRef
21. Davies MA, Lu Y, Sano T, et al. Adenoviral transgene expression of / MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. / Cancer Res. 1998;58:5285-290.
22. Davies MA, Koul D, Dhesi H, et al. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. / Cancer Res. 1999;59:2551-556.
23. Hisatake J, O’Kelly J, Uskokovic MR, Tomoyasu S, Koeffler HP. Novel vitamin D3 analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. / Blood. 2001;97:2427-433. CrossRef
24. Lee YR, Shim HJ, Yu HN, et al. Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells. / Leuk Res. 2005;29:401-05. CrossRef - 作者单位：Young-Rae Lee (1)
Hong-Nu Yu (1)
Eun-Mi Noh (1)
Jong-Suk Kim (1)
Eun-Kyung Song (1)
Myung-Kwan Han (2)
Byeong-Soo Kim (3)
Sung-Ho Lee (3)
Jinny Parkd (4)
1. Department of Biochemistry, Chonbuk National University Medical School, 560-180, Jeonju, Korea
2. Department of Microbiology & Immunology, Chonbuk National University Medical School, Jeonju, Korea
3. Department of Companion and Laboratory Animal Science, Kongju National University, Yesan, Korea
4. Division of Hematology/Oncology, Gachon University Medical Center, Inchon, Korea
文摘
Peroxisome proliferator-activated receptor γ (PPARγ) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARγ and RAR could synergistically up-regulate PTEN in human leukemia cells and consequently potentiate the inhibition of growth and cell cycle progression of these cells. We found that overexpression of PTEN with the adenoviral vector Ad/PTEN caused growth arrest at the G1 phase of the cell cycle of HL-60 cells. HL-60 cells treated with either a PPARγ ligand (ciglitazone) or a RAR ligand(all-trans retinoic acid [ATRA]) up-regulated PTEN in HL-60 cells. The 2 compounds in combination showed synergistic effects on PTEN expression at the protein and messenger RNA levels. Moreover, the combination of ciglitazone and ATRA synergistically reduced cell growth rates and cell cycle arrest at the G1 phase. Our results suggest that, PPARγ and RAR play an important role in controlling the growth of leukemia cells via the up-regulation of PTEN.