Anti-adipogenic activity of blue mussel (Mytilus edulis) extract by regulation of 3T3-L1 adipogenesis through Wnt/β-catenin signaling pathway

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• 作者：Myung-Soo Shon ; Si-Kyung Kim ; Ji-Hye Song…
• 关键词：Mytilus edulis ; mussel ; obesity ; adipogenesis ; Wnt/β ; catenin
• 刊名：Food Science and Biotechnology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：24
• 期：1
• 页码：315-321
• 全文大小：363 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

The blue mussel (Mytilus edulis) is widely distributed in European waters but it is little consumed. Although several studies have been reported biological activities of mussels, the anti-adipogenic activity of blue mussel and the molecular mechanism in anti-obese activity remain unknown. Here, we prepared a water extract of blue mussel (BME) and its anti-adipogenic activity was assessed in 3T3-L1 cells. BME treatment dose-dependently inhibited 3T3-L1 lipid accumulation, as judged by Oil Red O staining and microscopic analysis. Consistent with this, BME treatment markedly suppressed mRNA expression levels of adipogenic genes, such as C/EBPβ, PPARγ, C/EBPα, and FAS, in 3T3-L1 mature adipocytes. BME-inhibited lipid accumulation in 3T3-L1 adipocytes was limited with treatment after adipocyte differentiation, particularly in the early and intermediate stages. We also showed that the Wnt/β-catenin signaling pathway is required in BME-inhibited 3T3-L1 adipogenesis. These finding may provide scientific evidence for the development of functional foods against obesity.