Omental mesenteric myxoid hamartoma, a subtype of inflammatory myofibroblastic tumor? Considerations based on the histopathological evaluation of four cases

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• 作者：K. Ludwig ; R. Alaggio ; P. Dall’Igna ; E. Lazzari ; E. S. G. d’Amore…
• 关键词：Omental myxoid hamartomas of the peritoneum ; Peritoneal tumors ; Subserosal cells ; Submesothelial tissue ; Myofibroblast ; Inflammatory myofibroblastic tumor ; Inflammatory fibrosarcoma
• 刊名：Virchows Archiv
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：467
• 期：6
• 页码：741-747
• 全文大小：895 KB
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• 作者单位：K. Ludwig (1)
  R. Alaggio (1)
  P. Dall’Igna (2)
  E. Lazzari (3)
  E. S. G. d’Amore (3)
  P. M. Chou (4)
  
  1. Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University-Hospital of Padua, Via A. Gabelli 61, 35121, Padua, Italy
  2. Department of Woman and Children’s Health, Pediatric Surgery Unit, University-Hospital of Padua, Via Giustiniani 3, 35121, Padua, Italy
  3. Pathology Department, “San Bortolo-Hospital, Vicenza, Viale Rodolfi 37, 36100, Vicenza, Italy
  4. Department of Pathology, Northwestern University, 303 East Chicago Avenue, Chicago, IL, 60611, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2307

文摘

Omental mesenteric myxoid hamartoma (OMH) is a distinctive myxoid lesion of infancy, characterized by a benign clinical behavior. In the current World Health Organization (WHO) classification of soft tissue tumors, it is considered as part of the morphologic spectrum of inflammatory myofibroblastic tumors (IMT), but this relationship with IMT is still subject to debate. Four lesions with histologic features of OMH occurring in newborns and toddlers are described and compared with classic, ALK-positive IMT. All OMH showed a peculiar dot-like immunostaining for ALK, which, in one of the cases, was cytogenetically found to be associated with an inversion of the ALK gene. While OMHs were positive for smooth muscle actin (SMA), desmin, WT1, podoplanin, and cytokeratins (CAM5.2 and AE1-3), IMT were consistently positive only for SMA (10 cases). ALK-1 displayed cytoplasmic staining in IMT and characteristic paranuclear dot-like staining in OMH. Keywords Omental myxoid hamartomas of the peritoneum Peritoneal tumors Subserosal cells Submesothelial tissue Myofibroblast Inflammatory myofibroblastic tumor Inflammatory fibrosarcoma