Structure, function, and epigenetic regulation of BNIP3: a pathophysiological relevance
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- 作者：Nagarjuna Vasagiri (1) (2)
Vijay Kumar Kutala (1) - 关键词：BNIP3 ; Apoptosis ; Autophagy ; Epigenetic regulations ; Mitochondrial permeabilization
- 刊名：Molecular Biology Reports
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：41
- 期：11
- 页码：7705-7714
- 全文大小：776 KB
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Vijay Kumar Kutala (1)
1. Department of Clinical Pharmacology and Therapeutics, Nizam鈥檚 Institute of Medical Sciences, Hyderabad, India
2. Centre for Cellular and Molecular Biology Annexure II, Habsiguda, Hyderabad, A.P., India - ISSN：1573-4978
文摘
BCL-2 [B-cell leukemia/lymphoma 2]/adenovirus E1B 19KD interacting protein 3 (BNIP3) is an atypical BH3 domain only containing member of Bcl2 family of proteins. BNIP3 is known to be involved in various cellular processes depending on the cell type and conditions and also shown to play a role in various disease conditions including myocardial ischemia, autophagy and apoptosis. Though its role in autophagy and its pro-death activity have been reported in various studies, recent findings have shown its contradictory role in the regulation of these cellular processes. The various studies have shown its epigenetic regulation in disease development and progression and also found to be cytoprotective. In this review, we have focused on the structural and functional aspects of BNIP3 in relation to recent advances of its role in autophagy and apoptosis. Also its role of epigenetic regulation of several genes involved in various diseases was also discussed.