CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4

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• 作者：Takashi Nagasawa (1) (2)
  
• 关键词：Chemokine ; Bone marrow ; Niche ; Stem cells ; Hematopoietic stem cells (HSCs) ; B cell ; Homing ; Endothelial cells ; Angiogenesis ; Neurogenesis
• 刊名：Journal of Molecular Medicine
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：92
• 期：5
• 页码：433-439
• 全文大小：516 KB
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• 作者单位：Takashi Nagasawa (1) (2)
  
  1. Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan
  2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo, Japan
  
• ISSN：1432-1440

文摘

Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and maintenance of hematopoietic stem cells (HSCs), production of immune cells, homing of primordial germ cells (PGCs), cardiogenesis, arterial vessel branching in some organs, and appropriate assemblies of particular types of neurons. This review focuses on the pathophysiological relevance of CXCL12-CXCR4 signaling in mammals.