The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease

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• 作者：Naruhiko Ishiwada ; Kenichi Takeshita ; Takashi Yaguchi ; Koo Nagasawa…
• 关键词：Emericella nidulans var. echinulata ; Rasamsonia piperina ; Chronic granulomatous disease ; Voriconazole ; Micafungin
• 刊名：Mycopathologia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：181
• 期：3-4
• 页码：305-309
• 全文大小：874 KB
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• 作者单位：Naruhiko Ishiwada (1)
  Kenichi Takeshita (2)
  Takashi Yaguchi (3)
  Koo Nagasawa (2)
  Noriko Takeuchi (1)
  Haruka Hishiki (2)
  Akira Watanabe (1)
  Katsuhiko Kamei (1)
  Naoki Shimojo (2)
  
  1. Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan
  2. Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
  3. Division of Bioresources, Medical Mycology Research Center, Chiba University, Chiba, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Medical Microbiology
  Plant Sciences
  Microbial Ecology
  
• 出版者：Springer Netherlands
• ISSN：1573-0832

文摘

A 16-year-old boy with chronic granulomatous disease presented with pneumonia and rib osteomyelitis. Emericella nidulans var. echinulata was isolated from his sputum. After starting voriconazole, Rasamsonia piperina was isolated from the rib swelling. A combination therapy of voriconazole and micafungin effectively eradicated this invasive mixed-mold infection. In immunocompromised patients, a precise pathogenic diagnosis is clinically useful for administration of an appropriate treatment regimen.