Endogenous and Exogenous Calcium Involved in the Betulin Production from Submerged Culture of Phellinus linteus Induced by Hydrogen Sulfide
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- 作者：Guizhi Fan ; Duan Jian ; Meiling Sun ; Yaguang Zhan…
- 关键词：Hydrogen sulfide (H2S) ; Ca2+ ; Betulin ; Phellinus linteus ; Submerged culture
- 刊名：Applied Biochemistry and Biotechnology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：178
- 期：3
- 页码：594-603
- 全文大小：2,466 KB
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Duan Jian (1)
Meiling Sun (1)
Yaguang Zhan (1)
Feifei Sun (1)
1. College of Life Science, Northeast Forestry University, Harbin, People’s Republic of China
2. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Biotechnology
Biochemistry - 出版者：Humana Press Inc.
- ISSN：1559-0291
文摘
Using pharmacological and biochemical approaches, Ca2+ involved in the betulin production in mycelia of Phellinus linteus induced by hydrogen sulfide (H2S) were investigated. The results showed that 2 mM H2S donor NaHS or 10 mM CaCl2 was found to enhance the betulin content in the mycelia of Phellinus to the maximum, which were 112.43 and 93.24 % higher than that in the control, respectively. Further, NaHS and CaCl2 co-treatment also showed positive outcome, which were 128.95 or 24.52 % higher than that in the control or NaHS treatment. At the same time, NaHS also enhanced the content of Ca2+ and CaM. But, the above positive inductive effects for Ca2+, CaM, and betulin production can be blocked with either Ca2+ channel blocker (LaCl3, 2-aminoethoxydiphenyl borate) or Ca2+ chelator (ethylenediaminetetraacetic acid (EDTA)). Among of them, betulin content was reduced 35.06 % by NaHS and EGTA to the minimum, and this reduction could be reversed by the application of CaCl2 (NaHS + EGTA + CaCl2). From above results, it can be concluded that endogenous and exogenous calcium involved in the betulin production from submerged culture of P. linteus induced by hydrogen sulfide.