Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB

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• 作者：Xi Chen ; Xi-shuang Liu
• 刊名：Journal of Zhejiang University SCIENCE B
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：17
• 期：3
• 页码：209-217
• 全文大小：1,264 KB
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• 作者单位：Xi Chen (1) (2)
  Xi-shuang Liu (1) (3)
  
  1. Medical College, Qingdao University, Qingdao, 266021, China
  2. Department of Gastroenterology, Yantai Municipal Laiyang Central Hospital, Yantai, 265200, China
  3. Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, 266071, China
  
• 刊物主题：Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1862-1783

文摘

This study investigated the alleviating effects of hydrogen sulfide (H₂S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 μmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H₂S. It was also found that H₂S may regulate cytokine expression by inhibiting the nuclear factor-κB (NF-κB) signaling pathway. In conclusion, our results demonstrated that H₂S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway.