Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China

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• 作者：Xiaolin Liu (1)
  Naiying Mao (2)
  Weisen Yu (1)
  Qing Chai (1)
  Hui Wang (1)
  Weidong Wang (1)
  Lijuan Wang (1)
  Zhaoguo Wang (1)
  Wenbo Xu (2)
  
• 刊名：Archives of Virology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：159
• 期：9
• 页码：2497-2502
• 全文大小：1,364 KB
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• 作者单位：Xiaolin Liu (1)
  Naiying Mao (2)
  Weisen Yu (1)
  Qing Chai (1)
  Hui Wang (1)
  Weidong Wang (1)
  Lijuan Wang (1)
  Zhaoguo Wang (1)
  Wenbo Xu (2)
  
  1. Qingdao Center for Disease Control and Prevention, Qingdao, 266033, Shandong, People鈥檚 Republic of China
  2. National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Room 607, Beijing, 102206, People鈥檚 Republic of China
  
• ISSN：1432-8798

文摘

To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.