Detection of pleural lymph flow using indocyanine green fluorescence imaging in non-small cell lung cancer surgery: a preliminary study

详细信息    查看全文

• 作者：Kazuhiro Imai (1)
  Yoshihiro Minamiya (1)
  Hajime Saito (1)
  Taku Nakagawa (1)
  Manabu Ito (1)
  Takashi Ono (1)
  Satoru Motoyama (1)
  Yusuke Sato (1)
  Hayato Konno (1)
  Jun-ichi Ogawa (1)
  
• 关键词：Thoracic surgery ; Lung cancer ; Subpleural lymph flow ; Sentinel lymph node ; Indocyanine green
• 刊名：Surgery Today
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：43
• 期：3
• 页码：249-254
• 全文大小：337KB
• 参考文献：1. Riquet M. Anatomic basis lymphatic spread from carcinoma of the lung to the mediastinum: surgical and prognostic implications. Surg Radiol Anat. 2001;15:271-. CrossRef
  2. Tateishi M, Fukuyama Y, Hamatake M, Kohdono S, Ishida T, Sugimachi K. Skip mediastinal lymph node metastasis in non-small cell lung cancer. J Surg Oncol. 1994;57:139-2. CrossRef
  3. Tsubota N, Yoshimura M. Skip metastasis and hidden N2 disease in lung cancer: how successful is mediastinal dissection? Surg Today. 1996;26:169-2. CrossRef
  4. Yoshino I, Yokoyama H, Yano T, Ueda T, Takai E, Mizutani K, et al. Skip metastasis to the mediastinal lymph nodes in non-small cell lung cancer. Ann Thorac Surg. 1996;62:1021-. CrossRef
  5. Prenzel KL, Baldus SE, M?nig SP, Tack D, Sinning JM, Gutschow CA, et al. Skip metastasis in nonsmall cell lung carcinoma: predictive markers and isolated tumor cells in N1 lymph nodes. Cancer. 2004;100:1909-7. CrossRef
  6. Tanaka F, Takenaka K, Oyanagi H, Fujinaga T, Otake Y, Yanagihara K, et al. Skip mediastinal nodal metastases in non-small cell lung cancer. Eur J Cardiothorac Surg. 2004;25:1114-0. CrossRef
  7. Keller SM, Vangel MG, Wagner H, Schiller JH, Herskovic A, Komaki R, et al. Prolonged survival in patients with resected non-small cell lung cancer and single-level N2 disease. J Thorac Cardiovasc Surg. 2004;128:130-. CrossRef
  8. Kitai T, Inomoto T, Miwa M, Shikayama T. Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer. Breast Cancer. 2005;12:211-. CrossRef
  9. Miyashiro I, Miyoshi N, Hiratsuka M, Kishi K, Yamada T, Ohue M, et al. Detection of sentinel node in gastric cancer surgery by indocyanine green fluorescence imaging: comparison with infrared imaging. Ann Surg Oncol. 2008;15:1640-. CrossRef
  10. Ishikawa K, Yasuda K, Shiromizu A, Etoh T, Shiraishi N, Kitano S. Laparoscopic sentinel node navigation achieved by infrared ray electronic endoscopy system in patients with gastric cancer. Surg Endosc. 2007;21:1131-. CrossRef
  11. Nimura H, Narimiya N, Mitsumori N, Yamazaki Y, Yanaga K, Urashima M. Infrared ray electronic endoscopy combined with indocyanine green injection for detection of sentinel nodes of patients with gastric cancer. Br J Surg. 2004;91:575-. CrossRef
  12. Sobin LH, Gospodarowicz MK, Wittekind Ch, editors. TNM classification of malignant tumours. 7th ed. New York: Wiley; 2009.
  13. Nakagawa T, Minamiya Y, Katayose Y, Saito H, Taguchi K, Imano H, et al. A novel method for sentinel lymph node mapping using magnetite in patients with nonsmall cell lung cancer. J Thorac Cardiovasc Surg. 2003;126:563-. CrossRef
  14. Nomori H, Kohno M, Izumi Y, Ohtsuka T, Asakura K, Nakayama T. Sentinel nodes in lung cancer: review of our 10-year experience. Surg Today. 2011;41:889-5. CrossRef
  15. Minamiya Y, Ito M, Katayose Y, Saito H, Imai K, Sato Y, et al. Intraoperative sentinel lymph node mapping using a new sterilizable magnetometer in patients with nonsmall cell lung cancer. Ann Thorac Surg. 2006;81:327-0. CrossRef
  16. Kusano M, Tajima Y, Yamazaki K, Kato M, Watanabe M, Miwa M. Sentinel node mapping guided by indocyanine green fluorescence imaging: a new method for sentinel node navigation surgery in gastrointestinal cancer. Digest Surg. 2008;25:103-. CrossRef
  17. Yoneya S, Saito T, Komatsu Y, Koyama I, Takahashi K, Duvoll-Young J. Binding properties of indocyanine green in human blood. Invest Ophthalmol Vis Sci. 1998;39:1286-0.
  18. Casali C, Stefani A, Natali P, Rossi G, Morandi U. Prognostic factors in surgically resected N2 non-small cell lung cancer: the importance of patterns of mediastinal lymph nodes metastases. Eur J Cardiothorac Surg. 2005;28:33-. CrossRef
  
• 作者单位：Kazuhiro Imai (1)
  Yoshihiro Minamiya (1)
  Hajime Saito (1)
  Taku Nakagawa (1)
  Manabu Ito (1)
  Takashi Ono (1)
  Satoru Motoyama (1)
  Yusuke Sato (1)
  Hayato Konno (1)
  Jun-ichi Ogawa (1)
  
  1. Department of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan
  
• ISSN：1436-2813

文摘

Purpose Lymphatic spread of lung carcinoma to the mediastinum is a key determinant of prognosis. The lymph flow often carries metastases from the pulmonary segment directly into the mediastinal lymph nodes, without passing through the hilar nodes. This phenomenon is termed as “skip metastasis.-This study investigated the subpleural lymphatic flow to the mediastinum using indocyanine green (ICG) with a near-infrared fluorescence imaging system. Methods Seventeen patients with lung cancer were enrolled in this study. A 0.3?ml sample of solution containing the fluorescent dye ICG (5?mg/ml) was injected into subpleural sites near the primary tumor. Fluorescence imaging was used to monitor the flow of ICG-containing lymph from the injection site for 5?min. The relationship between the anatomical segment of the primary tumor and the lymphatic flow was assessed. Results The lymphatic vessels draining from the injection site were revealed by the bright ICG fluorescence in 14 of the patients (82.4?%). A direct lymphatic flow to the mediastinum was confirmed in 3 of those 14 (21.4?%). Conclusions These findings confirm the direct flow of lymph to the mediastinum without passage through the hilum pulmonis intraoperatively. These preliminary results may provide a valuable clue for further investigations of the mechanisms underlying skip metastasis.