A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of t

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• 作者：Yasunobu Sekiguchi (1)
  Asami Shimada (1) (3)
  Hidenori Imai (1)
  Mutsumi Wakabayashi (1)
  Keiji Sugimoto (1)
  Noriko Nakamura (2)
  Tomohiro Sawada (2)
  Yasunori Ohta (4)
  Norio Komatsu (3)
  Masaaki Noguchi (1)
  
  1. Department of Hematology ; Juntendo University Urayasu Hospital ; 2-1-1 Tomioka ; Urayasu ; Chiba ; Japan
  3. Department of Hematology ; Juntendo University Hospital ; Urayasu ; Japan
  2. Department of Clinical Laboratory ; Juntendo University Urayasu Hospital ; Urayasu ; Japan
  4. Department of Pathology ; Research Hospital ; The Institute of Medical Science ; The University of Tokyo ; Tokyo ; Japan
  
• 关键词：Double hit lymphoma ; BCL ; 2 ; C ; MYC ; Diffuse large B ; cell lymphoma ; Thyroid
• 刊名：Indian Journal of Hematology and Blood Transfusion
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：30
• 期：1-supp
• 页码：166-173
• 全文大小：1,734 KB
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• 刊物主题：Hematology; Oncology; Blood Transfusion Medicine; Human Genetics;
• 出版者：Springer India
• ISSN：0974-0449

文摘

A 50-year-old woman who presented with a mass in the thyroid gland was diagnosed as having diffuse large B-cell lymphoma (DLBCL) by biopsy in August 2011. The tumor had a complex chromosomal karyotype, including 8q24 (C-MYC) and 18q21(BCL-2), and fluorescence in situ hybridization confirmed split signals of C-MYC and BCL-2. BCL-2/IgH and C-MYC/IgH fusion signals were also observed. Three courses of rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone (R-CHOP) therapy were given, followed by thyroid gland irradiation. She was achieved complete remission (CR). In January 2012, a mass appeared in the right breast, which was diagnosed as relapse by biopsy. CR was achieved again after the 4th course of R-CHOP therapy, and one course of rituximab, etoposide, methylprednisolone, cytarabine, cisplatin (R-ESHAP) therapy was given. Thereafter, CR has been maintained after high-dose chemotherapy and autologous peripheral blood stem cell transplantation. There have been only 3 reported cases of primary thyroid C-MYC and BCL-2 double-hit lymphoma, including the present case; 2 of the cases were cases of DLBCL. R-CHOP therapy, irradiation and autologous peripheral blood stem cell transplantation are expected to be effective for such patients.