Case Report: Adrenal Oncocytoma Associated with Markedly Increased FDG Uptake and Immunohistochemically Positive for GLUT1

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• 作者：Naomi Sato (1)
  Yasuhiro Nakamura (1)
  Kentaro Takanami (2)
  Yoshikiyo Ono (3)
  Kei Omata (3)
  Ryo Morimoto (3)
  Fumitoshi Satoh (3)
  Kazue Ise (1)
  Shigeyuki Yamada (4)
  Atsuko Kasajima (1)
  Fumiyoshi Fujishima (1)
  Mika Watanabe (1)
  Yoichi Arai (4)
  Hironobu Sasano (1)
  
• 关键词：Adrenal gland ; Oncocytoma ; FDG ; PET ; GLUT1
• 刊名：Endocrine Pathology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：25
• 期：4
• 页码：410-415
• 全文大小：7,533 KB
• 参考文献：1. Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M (2013) Adrenal oncocytic neoplasm: a systematic review. Urol Int 91:125-33. CrossRef
  2. Wong DD, Spagnolo DV, Bisceglia M, Havlat M, McCallum D, Platten MA (2011) Oncocytic adrenocortical neoplasms--a clinicopathologic study of 13 new cases emphasizing the importance of their recognition. Hum Pathol 42:489-99. CrossRef
  3. Sasano H, Suzuki T, Sano T, Kameya T, Sasano N, Nagura H (1991) Adrenocortical oncocytoma. A true nonfunctioning adrenocortical tumor. Am J Surg Pathol 15:949-56. CrossRef
  4. Kim DJ, Chung JJ, Ryu YH, Hong SW, Yu JS, Kim JH (2008) Adrenocortical oncocytoma displaying intense activity on 18F-FDG-PET: a case report and a literature review. Ann Nucl Med 22:821-24. CrossRef
  5. Acar C, Akkas BE, Sen I, Sozen S, Kitapci MT (2008) False positive 18F-FDG PET scan in adrenal oncocytoma. Urol Int 80:444-47. CrossRef
  6. Minamimoto R, Yamanaka S, Kawamoto M, Endoh M, Nishito R, Yoshida K, Nakaigawa N, Yao M, Kubota Y, Inoue T (2007) High FDG uptake on oncocytoma located in the retroperitoneum mimicking malignancy. Clin Nucl Med 32:582-83. CrossRef
  7. John N. Eble, Guido Sauter, Jonathan I. Epstein, Isabell A. Sesterhenn. World Health Organization Classification of Tumours (2004). Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARCPress 42.
  8. Leon Barnes, John W. Eveson, Peter Reichart, David Sidransky. World Health Organization Classification of Tumours (2005). Pathology and Genetics of Head and Neck Tumours. IARCPress 266.
  9. Duregon E, Volante M, Cappia S, Cuccurullo A, Bisceglia M, Wong DD, Spagnolo DV, Szpak-Ulczok S, Bollito E, Daffara F, Berruti A, Terzolo M, Papotti M (2011) Oncocytic adrenocortical tumors: diagnostic algorithm and mitochondrial DNA profile in 27 cases. Am J Surg Pathol 35:1882-893. CrossRef
  10. Lee R, Al-Ahmadie HA, Boorjian SA, Gonzalez RR, Badillo C, Badillo F, Reuter VE, Steckel J (2006) A case of incidental adrenocortical oncocytoma. Nat Clin Pract Urol 3:618-21. CrossRef
  11. Bisceglia M, Ludovico O, Di Mattia A, Ben-Dor D, Sandbank J, Pasquinelli G, Lau SK, Weiss LM (2004) Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 12:231-43. CrossRef
  12. Bisceglia M, Ben-Dor D, Pasquinelli G (2005) Oncocytic Adrenocortical Tumors. Pathology Case Reviews 10 (5):228-42. CrossRef
  13. Sasano H, Suzuki T, Moriya T (2006) Recent advances in histopathology and immunohistochemistry of adrenocortical carcinoma. Endocr Pathol 17:345-54. CrossRef
  14. Schittenhelm J, Ebner FH, Harter P, Bornemann A (2009) Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol 20:73-7. CrossRef
  15. Hoang MP, Ayala AG, Albores-Saavedra J (2002) Oncocytic adrenocortical carcinoma: a morphologic, immunohistochemical and ultrastructural study of four cases. Mod Pathol 15:973-78. CrossRef
  16. Weiss LM (1984) Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 8:163-69. CrossRef
  17. Ni J, Qiu LJ, Hu LF, Cen H, Zhang M, Wen PF, Wang XS, Pan HF, Ye DQ (2014) Lung, liver, prostate, bladder malignancies risk in systemic lupus e
• 作者单位：Naomi Sato (1)
  Yasuhiro Nakamura (1)
  Kentaro Takanami (2)
  Yoshikiyo Ono (3)
  Kei Omata (3)
  Ryo Morimoto (3)
  Fumitoshi Satoh (3)
  Kazue Ise (1)
  Shigeyuki Yamada (4)
  Atsuko Kasajima (1)
  Fumiyoshi Fujishima (1)
  Mika Watanabe (1)
  Yoichi Arai (4)
  Hironobu Sasano (1)
  
  1. Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
  2. Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan
  3. Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Sendai, Japan
  4. Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
  
• ISSN：1559-0097

文摘

Usually, benign tumors are not associated with an increased F-18 fluorodeoxyglucose (F-18 FDG) uptake on positron emission tomography (PET), although some exceptions have been reported in adrenal neoplasms. We present a rare case of adrenocortical oncocytoma associated with markedly increased FDG uptake, demonstrating a maximum standardized uptake value of 46.8. Histological examination demonstrated diffuse proliferation of tumor cells with eosinophilic and granular cytoplasm that were diffusely immunopositive for mitochondria and glucose transport protein 1, with focal and?weak immunopositivity for 3β-hydroxysteroid dehydrogenase. Ultrastructural examination also revealed abundant mitochondria in the tumor cells. The tumor was diagnosed as adrenocortical oncocytoma and was considered benign according to Lin-Weiss-Bisceglia criteria. Diagnosis of adrenocortical oncocytoma can pose difficulties during both preoperative radiological and postoperative histopathological investigations.