Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg Syndrome): case report and literature review

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• 作者：Songdi Wu (1)
  Ningning Li (2)
  Feng Xia (3)
  Kastytis Sidlauskas (2)
  Xuemei Lin (1)
  Yihua Qian (4)
  Wei Gao (5)
  Qinlu Zhang (6)
  
  1. Department of Neurology ; First Hospital of Xi鈥檃n ; Xi鈥檃n ; Shaanxi ; 710002 ; China
  2. Division of Neuropathology ; Department of Neurodegenerative Disease ; Institute of Neurology ; University College London (UCL) ; London ; UK
  3. Department of Neurology ; Xijing Hospital ; The Fourth Military Medical University ; Xi鈥檃n ; Shaanxi ; China
  4. Department of Human Anatomy and Histology-Embryology ; Xi鈥檃n Jiaotong University College of Medicine ; Xi鈥檃n ; China
  5. Department of Ophthalmology ; First Hospital of Xi鈥檃n ; Xi鈥檃n ; Shaanxi ; China
  6. Xi鈥檃n GoldMag Nanobiotech Co. Ltd ; 2 Zhang Ba Wu Road ; Xi鈥檃n ; Shaanxi ; China
  
• 关键词：Dorsolateral medullary infarction ; Neurotrophic keratopathy ; Wallenberg syndrome
• 刊名：BMC Neurology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：3,622 KB
• 参考文献：1. Okada, Y, Reinach, PS, Kitano, A, Shirai, K, Kao, WW, Saika, S (2010) Neurotrophic keratopathy; its pathophysiology and treatment. Histol Histopathol 25: pp. 771-780
  2. Bonini, S, Rama, P, Olzi, D, Lambiase, A (2003) Neurotrophic keratitis. Eye 17: pp. 989-995 CrossRef
  3. Hipps, WM, Wilhelmus, KR (2004) Persistent visual loss from neurotrophic corneal ulceration after dorsolateral medullary infarction (Wallenberg syndrome). J Neuroophthalmol 24: pp. 345-346 CrossRef
  4. Marfurt, CF, Cox, J, Deek, S, Dvorscak, L (2010) Anatomy of the human corneal innervation. Exp Eye Res 90: pp. 478-492 CrossRef
  5. Wallenberg, A (1895) Akute Bulb盲raffektion (Embolie der Arteria cerebelli post inf sinistra). Archives fur Psychiatry 27: pp. 504-540 CrossRef
  6. Kameda, W, Kawanami, T, Kurita, K, Daimon, M, Kayama, T, Hosoya, T, Kato, T (2004) Lateral and medial medullary infarction: a comparative analysis of 214 patients. Stroke 35: pp. 694-699 CrossRef
  7. Conforto, AB, Yamamoto, FI, Leite Cda, C, Scaff, M, Marie, SK (2005) Facial sensory symptoms in medullary infarcts. Arq Neuropsiquiatr 63: pp. 946-950
  
• 刊物主题：Neurology; Neurochemistry; Neurosurgery;
• 出版者：BioMed Central
• ISSN：1471-2377

文摘

Background Dorsolateral medullary infarction (Wallenberg Syndrome) is rare in clinical practice; however, the subsequent corneal lesions are more uncommon. To our knowledge, only one such case was previously reported. We report a similar case with successful treatment and recovery, and analyse both cases to address the clinical features and outcomes of such syndrome. Case presentation A 43-year-old male presented with neurotrophic keratopathy one month after sustaining dorsolateral medullary infarction. The patient underwent amniotic membrane transplantation twice. Two-year follow-up observation revealed changes in nerve fibers and epithelial cells of corneal by laser confocal microscopy. Conclusion By studying both cases, we confirm that neurotrophic keratopathy could be as a delayed-onset complication of Wallenberg syndrome. The recognition that neurotrophic keratopathy can follow dorsolateral medullary infarction could prevent the clinical misdiagnosis.