Reduction-responsive zwitterionic nanogels based on carboxymethyl chitosan for enhancing cellular uptake in drug release

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• 作者：Liping Zhang ; Lin Xi ; Gang Shi ; Changping Zhu ; Caihua Ni
• 关键词：Nanogel ; Carboxymethyl chitosan ; Reduction sensitive ; Non ; fouling ; Cellular drug release
• 刊名：Colloid & Polymer Science
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：294
• 期：3
• 页码：629-637
• 全文大小：1,059 KB
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• 作者单位：Liping Zhang (1)
  Lin Xi (1)
  Gang Shi (1)
  Changping Zhu (2)
  Caihua Ni (1)
  
  1. The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China
  2. College of Computer and Information Engineering, Hohai University, Changzhou, People’s Republic of China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536

文摘

Stimuli-responsive nanoparticles as drug carriers have promising applications in chemotherapy. To increase stability of nanogels in the bloodstream and to enhance intracellular drug uptake, reduction-responsive zwitterionic nanogels were prepared using carboxymethyl chitosan as a material. The preparation included modification of carboxymethyl chitosan and crosslinking by of N,N-Bis(acryloyl) cystamine. The nanogels possessed zwitterions of carboxyl and amino groups, and showed excellent non-fouling behavior against protein adsorption. In the presence of a reduction agent such as glutathione (GSH), the nanogels were dissociated due to scission of disulfide bonds in the crosslinking structure, leading to drug release in tumor cells. The nanogels were non-cytotoxic, biocompatible, biodegradable, and would be potentially used as anticancer drug delivery carriers in controlled release for enhancing cellular drug uptake.