Modeling drug release from functionalized magnetic nanoparticles actuated by non-heating low frequency magnetic field
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- 作者：Y. Golovin ; D. Golovin ; N. Klyachko ; A. Majouga…
- 关键词：Magnetic nanoparticles ; Controlled release ; Modeling ; Drug delivery ; Drug release acceleration
- 刊名：Journal of Nanoparticle Research
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：19
- 期：2
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Nanotechnology; Inorganic Chemistry; Characterization and Evaluation of Materials; Physical Chemistry; Optics, Lasers, Photonics, Optical Devices;
- 出版者：Springer Netherlands
- ISSN：1572-896X
- 卷排序：19
文摘
Various plausible acceleration mechanisms of drug release from nanocarriers composed of a single-domain magnetic nanoparticle core with attached long macromolecule chains activated by low frequency non-heating alternating magnetic field (AMF) are discussed. The most important system characteristics affecting the AMF exposure impact are determined. Impact of several reasonable mechanisms is estimated analytically or obtained using numerical modeling. Some conditions providing manifold release acceleration as a result from exposure in AMF are found.