Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter
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- 作者：Naoki Kanegawa ; Yasushi Kiyono ; Hiroyuki Kimura ; Taku Sugita ; Satomi Kajiyama ; Hidekazu Kawashima ; Masashi Ueda ; Yuji Kuge and Hideo Saji
- 关键词：Norepinephrine transporter ; Radioiodination ; Brain ; SPECT ; (S ; S) ; 2 ; (a ; (2 ; iodo ; phenoxy)benzyl)morpholine
- 刊名：European Journal of Nuclear Medicine and Molecular Imaging
- 出版年：2006
- 出版时间：June 2006
- 年：2006
- 卷：33
- 期：6
- 页码：639-647
- 全文大小：329 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Nuclear Medicine
Imaging and Radiology
Orthopedics
Cardiology
Oncology - 出版者：Springer Berlin / Heidelberg
- ISSN：1619-7089
文摘
Purpose Abnormality of the brain norepinephrine transporter (NET) has been reported in several psychiatric and neuronal disorders. Since NET is an important target for the diagnosis of these diseases, the development of radiopharmaceuticals for imaging of brain NET has been eagerly awaited. In this study, we synthesized (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine [(S,S)-IPBM], a derivative of reboxetine iodinated at position 2 of the phenoxy ring, and evaluated its potential as a radiopharmaceutical for imaging brain NET using SPECT.