Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG

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• 作者：Yasushi Kiyono ; Satomi Kajiyama ; Hiromi Fujiwara ; Naoki Kanegawa and Hideo Saji
• 关键词：MIBG ; Norepinephrine transporter ; Sympathetic nervous system ; Diabetes mellitus ; Polyol pathway
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2005
• 出版时间：August 2005
• 年：2005
• 卷：32
• 期：8
• 页码：993-997
• 全文大小：133 KB

文摘

Purpose Cardiac scintigraphic studies using 123I-labeled metaiodobenzylguanidine ([123I]MIBG) have demonstrated heterogeneous myocardial accumulation of MIBG in diabetes. The accumulation has been found to correlate with a heterogeneous decrease in the expression of norepinephrine transporter (NET). In diabetic peripheral nerve tissue, polyol pathways are activated and cause nerve dysfunction and degeneration. However, there has been little research on the polyol pathway and cardiac sympathetic nerves. Therefore, to assess the influence of the polyol pathway on cardiac sympathetic nervous function, we investigated the regional accumulation of MIBG and NET protein expression in diabetic model rats treated with aldose reductase inhibitor (ARI) for the blockade of polyol pathways.