Interrelationship of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus colonization within and between pneumococcal-vaccine na?ve mother-chil
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- 作者：Tinevimbo Shiri (1) (2)
Marta C Nunes (1) (2)
Peter V Adrian (1) (2)
Nadia Van Niekerk (1) (2)
Keith P Klugman (2) (3) (4)
Shabir A Madhi (1) (2) (3) - 关键词：Bacterial interaction ; Colonization ; Pneumococcal conjugate vaccine ; Pneumococcus ; Staphylococcus aureus ; Haemophilus influenzae
- 刊名：BMC Infectious Diseases
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：1,442 KB
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24. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/483/prepub - 作者单位：Tinevimbo Shiri (1) (2)
Marta C Nunes (1) (2)
Peter V Adrian (1) (2)
Nadia Van Niekerk (1) (2)
Keith P Klugman (2) (3) (4)
Shabir A Madhi (1) (2) (3)
1. Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
2. Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
3. National Institute for Communicable Diseases: a division of National Health Laboratory Service, Centre for Respiratory and Meningitis Pathogens, 1 Modderfontein Road, Sandringham, Johannesburg, South Africa
4. Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA, USA - ISSN：1471-2334
文摘
Background A high prevalence of bacterial nasopharyngeal co-infections has been reported in children, however, such data is limited in adults. We examined the interaction of Haemophilus influenzae, Staphylococcus aureus and Streptococcus pneumoniae pharyngeal colonization in mother-child dyads. Methods Pneumococcal-vaccine na?ve children and their mothers had pharyngeal swabs undertaken at 1.6, 2.5, 3.5, 4.5, 7.4, 9.5, 12.5, 16.2 and 24.2 months of child’s age. Swabs were cultured for S. pneumoniae, H. influenzae and S. aureus using standard microbiologic methods. Multivariate generalized estimating equation-models were used to explore the associations of the three bacteria within and between children and their mothers. Results In children, the observed probability of co-colonization was higher than expected. Well-defined associations in colonization between the bacteria were observed in children but not among mothers. In children, a synergistic association was observed between S. pneumoniae and H. influenzae (Adjusted odds ratio (AOR): 1.75, 95% CI: 1.32-2.32) and a negative association between S. pneumoniae and S. aureus (AOR: 0.51, 95% CI: 0.39-0.67) or H. influenzae and S. aureus (AOR: 0.24, 95% CI: 0.16-0.34) colonization. Additionally, all three bacteria had a higher likelihood of concurrent colonization. There was a strong association in colonization by the bacteria in children and their mothers, including increased likelihood of maternal colonization if the child was colonized by S. pneumoniae (AOR: 1.84, 95% CI: 1.28-2.63) and H. influenzae (AOR: 6.34, 95% CI: 2.24-18.0). Conclusions The effects of immunization of children with pneumococcal-conjugate-vaccine in settings such as ours needs monitoring with regard to potential changes of pharyngeal bacterial ecology which could occur in vaccinated and –unvaccinated age-groups.