High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants
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- 作者：Marloes Vissers ; Inge M. Ahout ; Corné H. van den Kieboom…
- 关键词：Respiratory syncytial virus ; Streptococcus pneumoniae ; Disease severity ; Nasopharyngeal colonization ; MMP ; 9
- 刊名：BMC Infectious Diseases
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：867 KB
- 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2334
文摘
Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infections in infants. A small percentage of the infected infants develops a severe infection, while most of these severely ill patients were previously healthy. It remains unclear why these children develop severe RSV infections. In this study, we investigate whether pneumococcal nasopharyngeal carriage patterns correlate with mucosal inflammation and severity of disease.